TOMM20

TOMM20
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4APO
Identifiers
Aliases	TOMM20, MAS20, MOM19, TOM20, translocase of outer mitochondrial membrane 20
External IDs	OMIM: 601848 MGI: 1915202 HomoloGene: 44649 GeneCards: TOMM20
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	235,128,837 bp[1]
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)[2]
End	126,945,844 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• P-P-bond-hydrolysis-driven protein transmembrane transporter activity; • GO:0001948 protein binding; • mitochondrion targeting sequence binding; • unfolded protein binding; • protein transmembrane transporter activity;
Cellular component	• integral component of membrane; • ER-mitochondrion membrane contact site; • membrane; • mitochondrial outer membrane translocase complex; • integral component of mitochondrial outer membrane; • mitochondrial outer membrane; • mitochondrion; • mitochondrial envelope;
Biological process	• protein targeting; • tRNA import into mitochondrion; • mitochondrial outer membrane translocase complex assembly; • protein import into mitochondrial matrix; • protein transport; • intracellular protein transport; • protein targeting to mitochondrion; • protein deubiquitination; • response to muscle activity; • response to 3,3',5-triiodo-L-thyronine; • macroautophagy;
	Sources:Amigo / QuickGO
Orthologs
	9804
	67952
	ENSG00000173726
	ENSMUSG00000093904
	Q15388
	Q9DCC8
	NM_014765
	NM_024214
	NP_055580; NP_055580.1
	NP_077176
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial import receptor subunit TOM20 homolog is a protein that in humans is encoded by the TOMM20 gene.[5][6][7][8]

References

GRCh38: Ensembl release 89: ENSG00000173726 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000093904 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Seki N, Moczko M, Nagase T, Zufall N, Ehmann B, Dietmeier K, Schafer E, Nomura N, Pfanner N (Jan 1996). "A human homolog of the mitochondrial protein import receptor Mom19 can assemble with the yeast mitochondrial receptor complex". FEBS Lett. 375 (3): 307–10. doi:10.1016/0014-5793(95)01229-8. PMID 7498524. S2CID 45148104.
Goping IS, Millar DG, Shore GC (Nov 1995). "Identification of the human mitochondrial protein import receptor, huMas20p. Complementation of delta mas20 in yeast". FEBS Lett. 373 (1): 45–50. doi:10.1016/0014-5793(95)01010-C. PMID 7589431. S2CID 1204415.
Likic VA, Perry A, Hulett J, Derby M, Traven A, Waller RF, Keeling PJ, Koehler CM, Curran SP, Gooley PR, Lithgow T (Feb 2005). "Patterns that define the four domains conserved in known and novel isoforms of the protein import receptor Tom20". J Mol Biol. 347 (1): 81–93. doi:10.1016/j.jmb.2004.12.057. PMID 15733919.
"Entrez Gene: TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)".

Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
Schleiff E, Shore GC, Goping IS (1997). "Human mitochondrial import receptor, Tom20p. Use of glutathione to reveal specific interactions between Tom20-glutathione S-transferase and mitochondrial precursor proteins". FEBS Lett. 404 (2–3): 314–8. doi:10.1016/S0014-5793(97)00145-2. PMID 9119086. S2CID 29177508.
Schleiff E, Shore GC, Goping IS (1997). "Interactions of the human mitochondrial protein import receptor, hTom20, with precursor proteins in vitro reveal pleiotropic specificities and different receptor domain requirements". J. Biol. Chem. 272 (28): 17784–9. doi:10.1074/jbc.272.28.17784. PMID 9211931.
Schleiff E, Turnbull JL (1998). "Characterization of the N-terminal targeting signal binding domain of the mitochondrial outer membrane receptor, Tom20". Biochemistry. 37 (38): 13052–8. doi:10.1021/bi980746y. PMID 9748310.
Yano M, Kanazawa M, Terada K, et al. (1998). "Functional analysis of human mitochondrial receptor Tom20 for protein import into mitochondria". J. Biol. Chem. 273 (41): 26844–51. doi:10.1074/jbc.273.41.26844. PMID 9756929.
Hernández JM, Giner P, Hernández-Yago J (1999). "Gene structure of the human mitochondrial outer membrane receptor Tom20 and evolutionary study of its family of processed pseudogenes". Gene. 239 (2): 283–91. doi:10.1016/S0378-1119(99)00409-6. PMID 10548729.
Suzuki H, Okazawa Y, Komiya T, et al. (2001). "Characterization of rat TOM40, a central component of the preprotein translocase of the mitochondrial outer membrane". J. Biol. Chem. 275 (48): 37930–6. doi:10.1074/jbc.M006558200. PMID 10980201.
Yano M, Hoogenraad N, Terada K, Mori M (2000). "Identification and functional analysis of human Tom22 for protein import into mitochondria". Mol. Cell. Biol. 20 (19): 7205–13. doi:10.1128/MCB.20.19.7205-7213.2000. PMC 86274. PMID 10982837.
Abdul KM, Terada K, Yano M, et al. (2000). "Functional analysis of human metaxin in mitochondrial protein import in cultured cells and its relationship with the Tom complex". Biochem. Biophys. Res. Commun. 276 (3): 1028–34. CiteSeerX 10.1.1.379.8183. doi:10.1006/bbrc.2000.3589. PMID 11027586.
Mukhopadhyay A, Avramova LV, Weiner H (2002). "Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins". Arch. Biochem. Biophys. 400 (1): 97–104. doi:10.1006/abbi.2002.2777. PMID 11913975.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yano M, Terada K, Mori M (2003). "AIP is a mitochondrial import mediator that binds to both import receptor Tom20 and preproteins". J. Cell Biol. 163 (1): 45–56. doi:10.1083/jcb.200305051. PMC 2173431. PMID 14557246.
Yano M, Terada K, Mori M (2004). "Mitochondrial import receptors Tom20 and Tom22 have chaperone-like activity". J. Biol. Chem. 279 (11): 10808–13. doi:10.1074/jbc.M311710200. PMID 14699115.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Humphries AD, Streimann IC, Stojanovski D, et al. (2005). "Dissection of the mitochondrial import and assembly pathway for human Tom40". J. Biol. Chem. 280 (12): 11535–43. doi:10.1074/jbc.M413816200. PMID 15644312.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173726 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000093904 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7498524-5] Seki N, Moczko M, Nagase T, Zufall N, Ehmann B, Dietmeier K, Schafer E, Nomura N, Pfanner N (Jan 1996). "A human homolog of the mitochondrial protein import receptor Mom19 can assemble with the yeast mitochondrial receptor complex". FEBS Lett. 375 (3): 307–10. doi:10.1016/0014-5793(95)01229-8. PMID 7498524. S2CID 45148104.

[pmid7589431-6] Goping IS, Millar DG, Shore GC (Nov 1995). "Identification of the human mitochondrial protein import receptor, huMas20p. Complementation of delta mas20 in yeast". FEBS Lett. 373 (1): 45–50. doi:10.1016/0014-5793(95)01010-C. PMID 7589431. S2CID 1204415.

[pmid15733919-7] Likic VA, Perry A, Hulett J, Derby M, Traven A, Waller RF, Keeling PJ, Koehler CM, Curran SP, Gooley PR, Lithgow T (Feb 2005). "Patterns that define the four domains conserved in known and novel isoforms of the protein import receptor Tom20". J Mol Biol. 347 (1): 81–93. doi:10.1016/j.jmb.2004.12.057. PMID 15733919.

[entrez-8] "Entrez Gene: TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)".

TOMM20

See also

References

Further reading