TRNA-dihydrouridine20 synthase (NAD(P)+)

TRNA-dihydrouridine20 synthase (NAD(P)+) (EC 1.3.1.91, Dus2p, tRNA-dihydrouridine synthase 2) is an enzyme with systematic name tRNA-5,6-dihydrouracil20:NAD(P)+ oxidoreductase.[1][2][3][4] This enzyme catalyses the following chemical reaction

5,6-dihydrouracil20 in tRNA + NAD(P)+ uracil20 in tRNA + NAD(P)H + H+
TRNA-dihydrouridine20 synthase (NAD(P)+)
Identifiers
EC number1.3.1.91
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme specifically modifies uracil20 in tRNA.

References
  1. Xing F, Hiley SL, Hughes TR, Phizicky EM (April 2004). "The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs". The Journal of Biological Chemistry. 279 (17): 17850–60. doi:10.1074/jbc.M401221200. PMID 14970222.
  2. Xing F, Martzen MR, Phizicky EM (March 2002). "A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA". RNA. 8 (3): 370–81. doi:10.1017/S1355838202029825. PMC 1370258. PMID 12003496.
  3. Rider LW, Ottosen MB, Gattis SG, Palfey BA (April 2009). "Mechanism of dihydrouridine synthase 2 from yeast and the importance of modifications for efficient tRNA reduction". The Journal of Biological Chemistry. 284 (16): 10324–33. doi:10.1074/jbc.M806137200. PMC 2667719. PMID 19139092.
  4. Kato T, Daigo Y, Hayama S, Ishikawa N, Yamabuki T, Ito T, Miyamoto M, Kondo S, Nakamura Y (July 2005). "A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis". Cancer Research. 65 (13): 5638–46. doi:10.1158/0008-5472.CAN-05-0600. PMID 15994936.
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