TSEN15

tRNA-splicing endonuclease subunit Sen15 is an enzyme that in humans is encoded by the TSEN15 gene.[5][6][7]

TSEN15
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTSEN15, C1orf19, sen15, tRNA splicing endonuclease subunit 15, PCH2F
External IDsOMIM: 608756 MGI: 1913887 HomoloGene: 12002 GeneCards: TSEN15
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q25.3Start184,051,651 bp[1]
End184,123,978 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

116461

66637

Ensembl

ENSG00000198860

ENSMUSG00000014980

UniProt

Q8WW01

Q8R3W5

RefSeq (mRNA)

NM_001127394
NM_001300764
NM_001300766
NM_052965
NM_001363643

NM_025677

RefSeq (protein)

NP_001120866
NP_001287693
NP_001287695
NP_443197
NP_001350572

NP_079953

Location (UCSC)Chr 1: 184.05 – 184.12 MbChr 1: 152.37 – 152.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

tRNA splicing is a fundamental process for cell growth and division. SEN15 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM][7]

Interactions

C1orf19 has been shown to interact with TSEN2.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000198860 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000014980 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Sood R, Bonner TI, Makalowska I, Stephan DA, Robbins CM, Connors TD, et al. (April 2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics. 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID 11318611.
  6. Song J, Markley JL (February 2007). "Three-dimensional structure determined for a subunit of human tRNA splicing endonuclease (Sen15) reveals a novel dimeric fold". Journal of Molecular Biology. 366 (1): 155–64. doi:10.1016/j.jmb.2006.11.024. PMC 1865571. PMID 17166513.
  7. "Entrez Gene: C1orf19 chromosome 1 open reading frame 19".
  8. Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR (April 2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell. 117 (3): 311–21. doi:10.1016/S0092-8674(04)00342-3. PMID 15109492. S2CID 16049289.

Further reading


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