TSTA3

GDP-L-fucose synthetase is an enzyme that in humans is encoded by the TSTA3 gene.[5][6][7][8]

GFUS
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGFUS, FX, P35B, SDR4E1, tissue specific transplantation antigen P35B, TSTA3, GDP-L-fucose synthase
External IDsOMIM: 137020 MGI: 98857 HomoloGene: 2484 GeneCards: GFUS
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8q24.3Start143,612,618 bp[1]
End143,618,048 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

7264

22122

Ensembl

ENSG00000104522
ENSG00000278243

ENSMUSG00000022570

UniProt

Q13630

P23591

RefSeq (mRNA)

NM_003313
NM_001317783

NM_031201
NM_001357005

RefSeq (protein)

NP_001304712
NP_003304

NP_112478
NP_001343934

Location (UCSC)Chr 8: 143.61 – 143.62 MbChr 15: 75.92 – 75.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II.[8]

References

  1. ENSG00000278243 GRCh38: Ensembl release 89: ENSG00000104522, ENSG00000278243 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022570 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Camardella L, Carratore V, Ciardiello MA, Damonte G, Benatti U, De Flora A (Feb 1995). "Primary structure of human erythrocyte nicotinamide adenine dinucleotide phosphate (NADP[H])-binding protein FX: identification with the mouse tum- transplantation antigen P35B". Blood. 85 (1): 264–7. doi:10.1182/blood.V85.1.264.bloodjournal851264. PMID 7803801.
  6. Dyson PJ, de Smet C, Knight AM, Simon-Chazottes D, Guenet JL, Boon T (May 1992). "Mapping of the genes encoding tum- transplantation antigens P91A, P35B, and P198". Immunogenetics. 35 (5): 316–23. doi:10.1007/bf00189894. PMID 1348494. S2CID 9048773.
  7. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
  8. "Entrez Gene: TSTA3 tissue specific transplantation antigen P35B".

Further reading

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human GDP-L-fucose synthase


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