TXNRD1

Thioredoxin reductase 1, cytoplasmic is an enzyme that in humans is encoded by the TXNRD1 gene.[5]

TXNRD1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR, thioredoxin reductase 1
External IDsOMIM: 601112 MGI: 1354175 HomoloGene: 55733 GeneCards: TXNRD1
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q23.3Start104,215,779 bp[1]
End104,350,307 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

7296

50493

Ensembl

ENSG00000198431

ENSMUSG00000020250

UniProt

Q16881

Q9JMH6

RefSeq (mRNA)

NM_001042513
NM_001042514
NM_001042523
NM_015762

RefSeq (protein)

NP_001035978
NP_001035979
NP_001035988
NP_056577

Location (UCSC)Chr 12: 104.22 – 104.35 MbChr 10: 82.83 – 82.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.[6]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000198431 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020250 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Gasdaska PY, Gasdaska JR, Cochran S, Powis G (Nov 1995). "Cloning and sequencing of a human thioredoxin reductase". FEBS Lett. 373 (1): 5–9. doi:10.1016/0014-5793(95)01003-W. PMID 7589432. S2CID 735874.
  6. "Entrez Gene: TXNRD1 thioredoxin reductase 1".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.