Tableting

The manufacture of oral solid dosage forms such as tablets is a complex multi-stage process under which the starting materials change their physical characteristics a number of times before the final dosage form is produced.

Traditionally, tablets have been made by granulation, a process that imparts two primary requisites to formulate: compatibility and fluidity. Both wet granulation and dry granulation (slugging and roll compaction) are used. Regardless of whether tablets are made by direct compression or granulation, the first step, milling and mixing, is the same; subsequent steps differ.

Numerous unit processes are involved in making tablets, including particle size reduction and sizing, blending, granulation, drying, compaction, and (frequently) coating. Various factors associated with these processes can seriously affect content uniformity, bioavailability, or stability.

Sizing (size reduction, milling, crushing, grinding, pulverization) is an important step in the process of tablet manufacturing.

In manufacturing of compressed tablets, the mixing or blending of several solid pharmaceutical ingredients is easier and more uniform if the ingredients are about the same size. This provides a greater uniformity of dose. A fine particle size is essential in the case of lubricant mixing with granules for its proper function.

Advantages of smaller tablets are as follows:

• Increased surface area, which may enhance an active ingredient's dissolution rate and hence bioavailability
• Improved tablet-to-tablet content uniformity due to a larger number of particles per unit weight
• Controlled particle size distribution of dry granulation or mix to promote better flow of mixture in tablet machine
• Improved flow properties of raw materials
• Improved colour and/or active ingredient dispersion in tablet excipients
• Uniformly sized wet granulation to promote uniform drying

The following problems may arise if the process is not controlled properly:

• A possible change in polymorphic form of the active ingredient, rendering it less or totally inactive, or unstable
• A decrease in bulk density of active compound and/or excipients, which may cause flow problem and segregation in the mix
• An increase in surface area from size reduction may promote the adsorption of air, which may inhibit wettability of the drug to the extent that it becomes the limiting factor in dissolution rate

Various types of machine may be used for the dry sizing or milling process, depending on whether gentle screening or particle milling is needed. The range of equipment employed for this process includes:

• Fluid energy mill
• Colloidal mill
• Ball mill
• Hammer mill
• Cutting mill
• Roller mill
• Conical mill

The successful mixing of powder is more difficult than mixing liquid, as perfect homogeneity is difficult to achieve. Another problem is the inherent cohesiveness and resistance to movement between the individual particles. The process is further complicated in many systems by the presence of substantial segregation influencing the powder mix. This arises from the difference in size, shape, and density of the component particles. The powder/granules may be blended at the pre-granulation and/or post-granulation stage of tablet manufacturing. Each process of mixing has an optimum mixing time, and longer mixing may result in an undesired product. The optimum mixing time and speed must be evaluated. Blending prior to compression is normally achieved in a simple tumble blender. This be a fixed blender into which the powders are charged, blended and discharged. It is now common to use a bin blender from which the container (bin) can be removed and brought directly to other processing steps.[1] In special cases of mixing a lubricant, overmixing should be particularly monitored. The various blenders used include the "V" blender, oblicone blender, container blender, tumbling blender, and agitated powder blender.

Nowadays, to optimize the manufacturing process, particularly in wet granulation, various improved pieces of equipment which combines several processing steps (mixing, granulation and/or drying) are used. These are the mixer granulator and high shear mixing machine.

Following particle size reduction and blending, the formulation may be granulated, which provides homogeneity of drug distribution in the blend. This process is very important and needs experience to attain proper quality of granules before tableting. Quality of granule determines the smooth and trouble free process of tablets manufacturing. If granulation is not done in a proper manner, the resulting mixture may damage the tableting press.

Drying is an important step in the formulation and development of a pharmaceutical product. It is important to keep the residual moisture low enough to prevent product deterioration and ensure free flowing properties. The commonly used dryers include the fluidized-bed dryer, vacuum tray dryer, microwave dryer, spray dryer, freeze dryer, turbo-tray dryer, and pan dryer.

Compressed tablets can be round, oblong, or unique in shape; thick or thin; large or small in diameter; flat or convex; unscored or scored in halves, thirds, or quadrants; engraved or imprinted with an identifying symbol and/or code number; coated or uncoated; colored or uncolored; one, two, or three layered.

Tablet diameters and shapes are determined by the dies and punches used in compression. The less concave the punches, the flatter the tablets; conversely, the more concave the punches, the more convex the resulting tablets. Punches with raised impressions produce recessed impressions on the tablets; punches with recessed etchings produce tablets with raised impressions or monograms. Logos may be placed on one or on both sides of a tablet, depending on the punches.

Tablets must be packaged before they can be sent out for distribution. The type of packaging depends on the formulation of the medicine.

Blister packs are a common form of packaging. They are safe and easy to use, and the user can see the contents without opening the pack. Many pharmaceutical companies use a standard size of blister pack. This saves the cost of different tools and changing the production machinery between products. Sometimes the pack may be perforated so that individual tablets can be detached. This means that the expiry date and the drug's name must be printed on each part of the package. The blister pack itself must remain absolutely flat as it travels through the packaging processes, especially when it is inserted into a carton. Extra ribs are added to the blister pack to improve its stiffness.

The manufacturing of tablet involves numerous unit processes, including:

• Particle size reduction and sizing
• Blending
• Granulation
• Drying
• Compaction
• Testing of physical properties
• Coating[2]

• Sugar Confectionery Manufacture (1999) by E. B. Jackson, chapter 11.
• Hans-Jürgen Bässler und Frank Lehmann : Containment Technology: Progress in the Pharmaceutical and Food Processing Industry. Springer, Berlin 2013, ISBN 978-3642392917