Tirucalladienol synthase

Tirucalladienol synthase (EC 5.4.99.56, PEN3) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, tirucalla-7,24-dien-3beta-ol-forming).[1] This enzyme catalyses the following chemical reaction

(3S)-2,3-epoxy-2,3-dihydrosqualene tirucalla-7,24-dien-3beta-ol
Tirucalladienol synthase
Identifiers
EC number5.4.99.56
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The product from Arabidopsis thaliana is tirucalla-7,24-dien-3beta-ol.

References

  1. Morlacchi P, Wilson WK, Xiong Q, Bhaduri A, Sttivend D, Kolesnikova MD, Matsuda SP (June 2009). "Product profile of PEN3: the last unexamined oxidosqualene cyclase in Arabidopsis thaliana". Organic Letters. 11 (12): 2627–30. doi:10.1021/ol9005745. PMID 19445469.

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