Tom and Ray Magliozzi

In January 1987, Susan Stamberg of Weekend Edition on NPR asked the two brothers to contribute weekly to her program. Nine months later, Car Talk premiered as an independent NPR program. In 1992, Tom and Ray won a Peabody Award for Car Talk for "distinguished achievement and meritorious public service".[12][13] Tom and Ray continued to work in their repair garage while they produced Car Talk. On June 8, 2012, it was announced that Car Talk would stop producing new episodes in September 2012, though NPR would continue airing reruns of the show.[14]

Producer Doug Berman said that Tom and Ray "changed public broadcasting forever" because the brothers "showed that real people are far more interesting than canned radio announcers."[15] "The guys are culturally right up there with Mark Twain and the Marx Brothers."[16]

Harvard Square offices of "Dewey, Cheetham and Howe", headquarters of Car Talk

In addition to the radio show, Tom wrote for CarTalk.com and ran his own consulting business. In 1999, the brothers returned to MIT to deliver a joint commencement speech to the graduates.[17]

In 1989, the brothers started a newspaper column Click and Clack Talk Cars which, like the radio show, mixed serious advice with humor. King Features distributes the column. Ray continued to write the column, retitled Car Talk, after his brother's death in 2014, knowing he would have wanted the advice and humor to continue.[18]

Tom and Ray both appeared in the Pixar films Cars (2006) and Cars 3 (2017). (Tom's role in the third film was accomplished through archival recordings, as it was produced after his death. While Ray reprised his role despite his retirement in 2012.) They played the owners of Rust-eze who discovered Lightning McQueen and gave him his first big break. Tom appeared as a 1963 Dodge Dart convertible, a reference to a car that he owned for many years and often mentioned on Car Talk. Ray appeared as a 1964 Dodge A100 van. In both films, they admonished: "Don't drive like my brother", the catchphrase from the close of their radio show.[19]

The Magliozzi brothers also appeared in the sitcom Sabrina the Teenage Witch (1996 TV series) in an episode called "Driving Mr. Goodman" which aired on May 3, 2002. Sabrina calls them on a magical car radio for car advice.[20] In the same year they appeared in the PBS Kids show Arthur episode called "Pick a Car, Any Car" which aired on November 25, 2002. Arthur calls them with a question about the family car, which would have been hauled away by the local mechanic without their help. The answer turns out to be a baby rattle lodged in the car's tailpipe.[21] In 2008, the brothers starred in their own PBS animated series Click and Clack's As the Wrench Turns, playing fictionalized versions of themselves.[22] They also hosted an episode of the PBS show NOVA entitled "The Car of the Future".[23]