Transformer (gene)
Transformer (tra) is a family of genes which regulate sex determination in insects such as flies.[1][2] Among its effects, it (P11596) regulates differences between males and females in Drosophila fruit flies.[3]
| Female-specific protein transformer | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Tra | ||||||||
| Pfam | PF06495 | ||||||||
| InterPro | IPR010519 | ||||||||
| |||||||||
Alternative splicing of the Drosophila Transformer gene product.
The tra-2 gene (P19018) is needed for sexual differentiation in female fruit flies, and for spermatogenesis in the males. It is not in the same protein family as tra, but instead works together with it in the splicing enhancer complex.[4][5]
References
- Verhulst, Eveline C.; van de Zande, Louis; Beukeboom, Leo W. (August 2010). "Insect sex determination: it all evolves around transformer". Current Opinion in Genetics & Development. 20 (4): 376–383. doi:10.1016/j.gde.2010.05.001. PMID 20570131.
- "Gene Review. tra - transformer". Nature Genetics. Retrieved 7 December 2017.
- Kopp, Artyom; Rideout, Elizabeth J.; Narsaiya, Marcus S.; Grewal, Savraj S. (2015). "The Sex Determination Gene transformer Regulates Male-Female Differences in Drosophila Body Size". PLOS Genetics. 11 (12): e1005683. doi:10.1371/journal.pgen.1005683. PMC 4692505. PMID 26710087.
- Amrein, Hubert; Gorman, Monica; Nöthiger, Rolf (1988). "The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein". Cell. 55 (6): 1025–1035. doi:10.1016/0092-8674(88)90247-4. PMID 3144434.
- "Transformer-2 sex-determining protein". UniProt. Retrieved 7 December 2017.
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