UBR5

E3 ubiquitin-protein ligase UBR5 is an enzyme that in humans is encoded by the UBR5 gene.[5][6][7]

UBR5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesUBR5, DD5, EDD, EDD1, HYD, ubiquitin protein ligase E3 component n-recognin 5
External IDsOMIM: 608413 MGI: 1918040 HomoloGene: 9295 GeneCards: UBR5
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8q22.3Start102,252,273 bp[1]
End102,412,759 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

51366

70790

Ensembl

ENSG00000104517

ENSMUSG00000037487

UniProt

O95071

Q80TP3

RefSeq (mRNA)

NM_001282873
NM_015902

NM_001081359
NM_001112721
NM_027553

RefSeq (protein)

NP_001269802
NP_056986

NP_001074828
NP_001106192

Location (UCSC)Chr 8: 102.25 – 102.41 MbChr 15: 37.97 – 38.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation.[7]

Interactions

UBR5 has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000104517 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000037487 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Callaghan MJ, Russell AJ, Woollatt E, Sutherland GR, Sutherland RL, Watts CK (Mar 1999). "Identification of a human HECT family protein with homology to the Drosophila tumor suppressor gene hyperplastic discs". Oncogene. 17 (26): 3479–91. doi:10.1038/sj.onc.1202249. PMID 10030672.
  6. Tasaki T, Mulder LC, Iwamatsu A, Lee MJ, Davydov IV, Varshavsky A, Muesing M, Kwon YT (Aug 2005). "A Family of Mammalian E3 Ubiquitin Ligases That Contain the UBR Box Motif and Recognize N-Degrons". Mol Cell Biol. 25 (16): 7120–36. doi:10.1128/MCB.25.16.7120-7136.2005. PMC 1190250. PMID 16055722.
  7. "Entrez Gene: EDD1 E3 ubiquitin protein ligase, HECT domain containing, 1".
  8. Henderson MJ, Russell AJ, Hird S, Muñoz M, Clancy JL, Lehrbach GM, Calanni ST, Jans DA, Sutherland RL, Watts CK (Jul 2002). "EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response". J. Biol. Chem. 277 (29): 26468–78. doi:10.1074/jbc.M203527200. PMID 12011095.
  9. Eblen ST, Kumar NV, Shah K, Henderson MJ, Watts CK, Shokat KM, Weber MJ (Apr 2003). "Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs". J. Biol. Chem. 278 (17): 14926–35. doi:10.1074/jbc.M300485200. PMID 12594221.
  10. Honda Y, Tojo M, Matsuzaki K, Anan T, Matsumoto M, Ando M, Saya H, Nakao M (Feb 2002). "Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response". J. Biol. Chem. 277 (5): 3599–605. doi:10.1074/jbc.M104347200. PMID 11714696.

Further reading


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