Viral tegument

A viral tegument or tegument, more commonly known as a viral matrix, is a cluster of proteins that lines the space between the envelope and nucleocapsid of all herpesviruses.[1][2] The tegument generally contains proteins that aid in viral DNA replication and evasion of the immune response, typically with inhibition of signalling in the immune system and activation of interferons. The tegument is usually released shortly after infection into the cytoplasm. These proteins are usually formed within the late phase of the viral infectious cycle, after viral genes have been replicated. Much information regarding viral teguments has been gathered from studying Herpes simplex virus.[3]

Location of the viral tegument

Properties of teguments

Viral teguments can be symmetrically arranged via structural and scaffolding protein or can also be asymmetrically arranged, depending on the virus. Teguments are rarely haphazardly placed and usually involve scaffolding proteins in their formation around the nucleocapsid. Non-essential proteins included in the tegument may aid in immune response suppression, suppression of host mRNA transcription or suppression of intrinsic or cellular defenses. Essential proteins will include factors that help in trafficking of the viral capsid to the nucleus (for herpesviruses), recruiting host transcription or translation factors, or directly transcribing or translating viral genes. Tegumental contents are released into the cytoplasm upon entrance into the cell upon which many tegumental proteins become active. The tegument may also aid in insertion of the viral genome into host cell cytoplasm or nucleus.

References
  1. "Virion tegument". www.uniprot.org. Retrieved 7 May 2019.
  2. Yu, Xuekui; Shah, Sanket; Lee, Manfred; Dai, Wei; Lo, Pierrette; Britt, William; Zhu, Hua; Liu, Fenyong; Hong Zhou, Z. (2011). "Biochemical and structural characterization of the capsid-bound tegument proteins of human cytomegalovirus". Journal of Structural Biology. 174 (3): 451–460. doi:10.1016/j.jsb.2011.03.006. PMC 3684277. PMID 21459145.
  3. Mchamstien, Hamm Y.; Mable Mchamstien; Brian J. Yeung (April 2007). "Herpes Simplex Virus Tegument Protein V1 Elucidation and Formation Around the Nucleocapsid". Journal of Virology. American Society for Microbiology. 28 (2): 1262–1274.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.