Wee-Bey Brice

Wee-Bey is Barksdale's main soldier. When Avon is cleaning up any possible trail of evidence leading back to him, Wee-Bey kills a witness who had previously been bought off. Wee-Bey gets involved in two different gun fights with legendary stick-up man Omar Little, after torturing and killing Omar's partner, accomplice and lover Brandon. Their first encounter ends with Wee-Bey being shot in the leg, but he later defends Avon against Omar, shooting him in the shoulder and forcing him to retreat. Wee-Bey has the distinction of being the only character in the Wire to get the better of Omar in a one-to-one gunfight.

Wee-Bey was also linked to the body of a dancer from Orlando's strip club, a Barksdale front company. Although not responsible for her death, he slept with her the evening before and showed little concern after she died from a drug overdose. Disgusted with his callous disposal of her body, Shardene gives information to Lester Freamon.

His downfall comes when he and Little Man kill Orlando, who was working as a police informant. During the killing, Little Man shoots and critically wounds the undercover Kima Greggs, in the car with Orlando. Wee-Bey is stunned to learn that the second shooting victim was an undercover cop. Stringer orders Wee-Bey to kill Little Man, stating that he is unreliable as a soldier, and flee town; D'Angelo Barksdale is responsible for driving Wee-Bey to Philadelphia (and taking care of his fish). When D'Angelo is arrested soon after, he gives the police information concerning Wee-Bey's whereabouts and his murder of Deirdre Kresson, a former girlfriend of Avon's. Later, through a combination of the active wiretap and phone records, the police are able to determine Wee-Bey's exact location. To apprehend Wee-Bey unarmed, they lure him out of the house by having Carver break the windows on his car. Once in custody, and guaranteed a life sentence for his involvement in Kima's shooting, Wee-Bey confesses to other murders, including several he did not commit, to protect those in the Barksdale Organization.

Wee-Bey is imprisoned with Avon, serving life without parole. He keeps artificial fish in his cell and enjoys a relatively easy life under Barksdale's protection. A correctional officer named Dwight Tilghman harasses him because he confessed to murdering a relative of Tilghman's. Wee-Bey complains to Avon. Avon and Stringer resolve the problem by arranging for Tilghman to smuggle tainted drugs into the prison. When the bad drugs kill several inmates, Avon comes forward as an "informant" and implicates Tilghman as the culprit.

Dennis "Cutty" Wise is offered a position after Wee-Bey introduces him to Avon.

Wee-Bey's teenage son, Namond Brice, becomes involved in the drug trade with Bodie Broadus. Namond is responsible for Wee-Bey's fish. De'Londa and Namond visit Wee-Bey regularly and Wee-Bey gives Namond advice on life, especially about surviving on the streets. When Brianna Barksdale cuts off the monthly payments that the Barksdale organization had been making to the Brices, Namond is pressured into dealing by his mother. Howard "Bunny" Colvin takes a liking to Namond after dealing with him in the special program for troubled youth that Colvin is supervising. Seeing potential in the boy, Colvin approaches Wee-Bey and asks his permission to take Namond into his home. Colvin tells Wee-Bey that the changing face of the drug trade and Namond's capabilities in other areas make him better suited to a life off the streets. Though initially reluctant, Wee-Bey agrees that Colvin's offer gives Namond the best chance of escaping the drug trade and making something of himself. Acknowledging that anything would be preferable to a life as a soldier, Wee-Bey orders De'Londa to allow Colvin to assume guardianship of Namond, implicitly threatening her when she appears reluctant to let Namond go.

Wee-Bey is briefly seen during the end-of-season montage conversing amicably with Chris Partlow in the courtyard of the Maryland State prison; they are in a similar situation, both having been primary enforcers for West Baltimore kingpins, and now both serving life sentences for committing (and taking sole responsibility for) murders at the behest of their respective bosses.