William K. Oh

William K. Oh, is an American medical oncologist and expert in the management of genitourinary malignancies, including prostate, renal, bladder and testicular cancers.

William K. Oh, M.D.
EducationYale University, NYU
Medical career
Professionmedical oncologist
Institutions
Sub-specialtiesgenitourinary oncology
Researchcancer research

Oh is Chief of the Division of Hematology and Medical Oncology at The Mount Sinai Medical Center in New York City, Deputy Director at Mount Sinai's NCI-designated Tisch Cancer Institute, Professor of Medicine and Urology and the Ezra M. Greenspan, M.D., Professor in Clinical Cancer Therapeutics at The Icahn School of Medicine at Mount Sinai.[1]

In 2009, Oh presented at the American Society of Clinical Oncology the findings of a two-year study which showed that a six-gene molecular diagnostic test, when combined with a PSA test, improved to 90% the accuracy of prostate cancer detection over PSA tests alone.[2]

Oh is the author of more than 350 articles and 125 abstracts. He is the editor of 6 books and the author of 25 book chapters. He has been listed in Castle Connolly's "America's Top Doctors for Cancer" from 2008 to 2020, "Best Doctors in America" from 2003 to 2020, was listed among Boston Magazine's "Top Doctors" in 2005 and 2009 and New York Magazine's "Top Doctors" from 2010–2020.[1][3]

Biography

Oh was born in South Korea and immigrated to the US as a child. He earned a B.S. from Yale University in 1987 and his M.D. from New York University School of Medicine in 1992. He completed an internship and a residency at Brigham and Women's Hospital in Boston and a clinical fellowship at the Dana–Farber Cancer Institute.

From 1997 to 2009, Oh served on the faculty of Harvard Medical School, where he was Associate Professor of Medicine and Clinical Director of the Lank Center for Genitourinary Oncology. In 2009, he joined The Mount Sinai Medical Center as the Ezra M. Greenspan Professor in Clinical Cancer Therapeutics and Professor of Medicine and Urology, as well as Chief of the Division of Hematology and Medical Oncology in Mount Sinai's Department of Medicine.[1]

Oh is a leading member of the American Society of Clinical Oncology. He has served on multiple editorial boards including the journals The Prostate, Clinical Genitourinary Cancer, the American Journal of Hematology and Oncology and CA – A Cancer Journal for Clinicians.

He co-edited the book "Mount Sinai Expert Guides: Oncology" which was published in 2019.

Oh has been the principal investigator on multiple clinical trials of chemotherapy in castration-resistant (CRPC) prostate cancer[4][5] and for three trials of neoadjuvant chemotherapy in high-risk localized prostate cancer patients.

At the Dana–Farber Cancer Institute, from 2000 to 2009, Oh developed and managed a prospective clinical database linked to blood and tissue banks for more than 8,000 prostate cancer patients, with links to blood samples and tissue repositories, for exploration of research and prognostic applications, including: efficacy of various therapies in CRPC, hormonal therapy, testosterone as a marker for cancer outcome, relapse predictions based on nutritional factors at diagnosis and autoantibody signatures, and assessment of pharmacogenomic patterns predicting Gleason score.[6] At Mount Sinai, he has continued this work and developed a database of over 1500 patients.

Honors and awards
  • 1992 Alpha Omega Alpha[7]
  • 1992 Prize in Internal Medicine, NYU School of Medicine
  • 1997 ASCO/AACR Methods in Clinical Cancer Research Workshop[7]
  • 2003 Compassionate Caregiver of the Year, Kenneth B. Schwartz Center, Honorable Mention
  • 2003–present, Best Doctors in America
  • 2004 Award Recipient, Loan Repayment Program for Clinical Research, NIH
  • 2004–present, Who's Who in America
  • 2005 2009 Boston Magazine "Top Doctors"
  • 2007–2008 Brigham/Harvard Business School Physician Leadership Program
  • 2008–present, America's Top Doctors for Cancer (Castle Connolly)
  • 2010 Prostate Cancer Foundation Creativity Award
  • 2010–present, New York Magazine "Top Doctors"
  • 2011 Election to the American Society of Clinical Investigation
  • 2013 Fellow, American College of Physicians (FACP)
  • 2015 Newsweek "Top Doctors"

Publications

Partial list:

  • Febbo PG, Richie JP, George DJ, et al. (July 2005). "Neoadjuvant docetaxel before radical prostatectomy in patients with high-risk localized prostate cancer". Clin. Cancer Res. 11 (14): 5233–40. doi:10.1158/1078-0432.CCR-05-0299. PMID 16033841.CS1 maint: ref=harv (link)
  • Oh WK, Halabi S, Kelly WK, et al. (December 2003). "A phase II study of estramustine, docetaxel, and carboplatin with granulocyte-colony-stimulating factor support in patients with hormone-refractory prostate carcinoma: Cancer and Leukemia Group B 99813". Cancer. 98 (12): 2592–8. doi:10.1002/cncr.11829. PMID 14669278.CS1 maint: ref=harv (link)
  • Oh WK, Kantoff PW, Weinberg V, et al. (September 2004). "Prospective, multicenter, randomized phase II trial of the herbal supplement, PC-SPES, and diethylstilbestrol in patients with androgen-independent prostate cancer". J. Clin. Oncol. 22 (18): 3705–12. doi:10.1200/JCO.2004.10.195. PMID 15289492.CS1 maint: ref=harv (link)
  • Oh WK, Hagmann E, Manola J, et al. (January 2005). "A phase I study of estramustine, weekly docetaxel, and carboplatin chemotherapy in patients with hormone-refractory prostate cancer". Clin. Cancer Res. 11 (1): 284–9. PMID 15671557.CS1 maint: ref=harv (link)
  • Oh WK, Hayes J, Evan C, et al. (June 2006). "Development of an integrated prostate cancer research information system". Clin Genitourin Cancer. 5 (1): 61–6. doi:10.3816/CGC.2006.n.019. PMID 16859581.CS1 maint: ref=harv (link)
  • Oh WK, Hu J (February 2010). "Prostate Cancer: "Advances and Controversies in Prostate Cancer."". Urologic Clinics of North America. 37 (1): 1–148. doi:10.1016/j.ucl.2010.01.001. ISBN 978-1-4377-1916-1.CS1 maint: ref=harv (link)
  • Oh WK, Landrum MB, Lamont EB, McNeil BJ, Keating NL (March 2010). "Does oral antiandrogen use before leuteinizing hormone-releasing hormone therapy in patients with metastatic prostate cancer prevent clinical consequences of a testosterone flare?". Urology. 75 (3): 642–7. doi:10.1016/j.urology.2009.08.008. PMID 19962733.CS1 maint: ref=harv (link)
  • Ross RW, Oh WK, Xie W, et al. (February 2008). "Inherited variation in the androgen pathway is associated with the efficacy of androgen-deprivation therapy in men with prostate cancer". J. Clin. Oncol. 26 (6): 842–7. doi:10.1200/JCO.2007.13.6804. PMID 18281655.CS1 maint: ref=harv (link)

References
  1. "Mount Sinai Medical Center - Doctor profile".
  2. "New blood test greatly reduces false-positives in prostate cancer screenings – Dana-Farber Cancer Institute".
  3. "Castle Connolly Medical Ltd".
  4. Taplin ME, Regan MM, Ko YJ, Bubley GJ, Duggan SE, Werner L, Beer TM, Ryan CW, Mathew P, Tu SM, Denmeade SR, Oh WK, Sartor O, Mantzoros CS, Rittmaster R, Kantoff PW, Balk SP (November 2009). "Phase II study of androgen synthesis inhibition with ketoconazole, hydrocortisone, and dutasteride in asymptomatic castration-resistant prostate cancer". Clin. Cancer Res. 15 (22): 7099–105. doi:10.1158/1078-0432.CCR-09-1722. PMC 3644858. PMID 19887483.
  5. "Dana-Farber Cancer Institute Oncologists Present Results of Source MDx's RNA Transcript-Based Six-Gene Test to Predict Survival of Castration-Resistant Prostate Cancer Patients at GU ASCO Sym - News, Search Jobs, Events".
  6. Oh WK, Hayes J, Evan C, Manola J, George DJ, Waldron H, Donovan M, Varner J, Orechia J, Katcher B, Lu D, Nevins A, Wright RL, Tormey L, Talcott J, Rubin MA, Loda M, Sellers WR, Richie JP, Kantoff PW, Weeks J (June 2006). "Development of an integrated prostate cancer research information system". Clin Genitourin Cancer. 5 (1): 61–6. doi:10.3816/CGC.2006.n.019. PMID 16859581.
  7. "HealthGrades: Awards & Recognition for Dr. William Oh, MD".
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