Xibornol

Xibornol
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	J01XX02 (WHO) ;
Identifiers
	IUPAC name 4,5-dimethyl-2-[(1S,4R,6R)-1,7,7-trimethyl-6-bicyclo[2.2.1]heptanyl]phenol;
CAS Number	13741-18-9 ;
PubChem CID	11777299;
ChemSpider	9951982 ;
UNII	RQ12GMY0FZ;
KEGG	D07433 ;
ChEBI	CHEBI:131713 ;
ChEMBL	ChEMBL2104519;
CompTox Dashboard (EPA)	DTXSID60472406 ;
ECHA InfoCard	100.033.906
Chemical and physical data
Formula	C18H26O
Molar mass	258.405 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Oc1cc(c(cc1C2CC3CCC2(C)C3(C)C)C)C;
	InChI InChI=1S/C18H26O/c1-11-8-14(16(19)9-12(11)2)15-10-13-6-7-18(15,5)17(13,3)4/h8-9,13,15,19H,6-7,10H2,1-5H3 ; Key:RNRHMQWZFJXKLZ-UHFFFAOYSA-N ;
	(verify)

Xibornol is an antibiotic.

Overview

It is primarily administered to the throat.[1]

Xibornol is a lipophilic drug mainly used in Italy and Spain in spray dosage forms for the local treatment of infection and inflammation of the throat. Its poor water solubility makes difficult the development of aqueous formulations of the drug, thus giving rise to a limited number of stable and pharmaceutically accepted preparations. In fact, xibornol is actually marketed only as spray aqueous suspension.

References

Cirri M, Mura P, Mora PC (2007). "Liquid spray formulations of xibornol by using self-microemulsifying drug delivery systems". Int J Pharm. 340 (1–2): 84–91. doi:10.1016/j.ijpharm.2007.03.021. PMID 17531411.

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[pmid17531411-1] Cirri M, Mura P, Mora PC (2007). "Liquid spray formulations of xibornol by using self-microemulsifying drug delivery systems". Int J Pharm. 340 (1–2): 84–91. doi:10.1016/j.ijpharm.2007.03.021. PMID 17531411.