Zeke and Luther

• Nate Hartley as Oswald "Ozzie" Kepphart, a local power walker and a nerd who wears large glasses. He used to hate skateboarding but became a part-time skater, the first sport he did not quit after a day, and eventually became a good skater. He occasionally sticks his butt out as a rude gesture, which annoys Luther. When he skates, he flaps his arms as if he is attempting to fly.
• David Ury as Donald "Don" Donaldson, the owner and proprietor of Don's Donuts, Zeke and Luther's favorite hangout. In the episode "Luther Leads", Luther realizes that Don is the only one that works at Don's Donuts, although he hires more people in later episodes.
• Marianne Muellerleile as Dorothy Joanne "Nana" Waffles, Luther's grandmother. Nana lives in an apartment with her husband Carl. She often inspires Luther because he does not want to disappoint her loft view of him, and the boys often come to her aid when she is in trouble.
• Abigail Mavity as Lisa Grubner, a young, geeky girl who has an overwhelming crush on Zeke. She lives in a pink dollhouse in her parents' driveway and is an avid flautist and tumbler. Her first appearance was in the episode "Donut Jockey".
• Scott Beehner as Deputy Dingle, a bumbling police officer who is always onto Zeke and Luther's shenanigans, but is easily bribed by turkey jerky as seen in "Bro, Where's Our Car?". Although an officer, he is very stupid, and also can be strict.
• Lawrence Mandley as Reginald "Jumpsuit" Johnson, Zeke and Luther's cranky ex-astronaut neighbor who commonly growls and has a gravity simulator in his garage. His nickname is because he wears a jumpsuit every day. He once called Luther a menace but made no comment about Zeke.
• Ron Fassler as Dale Davis, a local television news reporter always on the scene of a big event.
• Tristin Mays as Monica Lopez, Kojo's on-and-off cheerleader girlfriend. She also appears in the episode "Bro, Where's Our Car?" as a Junior Miss Gilroy candidate who, alongside Bridget, is taken to the beach by Zeke and Luther in an attempt to woo them.
• Lily Jackson as Poochie McGruder (seasons 1–2), Ginger's cheerful friend who helps her to prank Zeke. She likes clapping at anything Ginger says or does, and her catchphrase is "Yay!". She wears glasses.
• Juliet Holland-Rose as Olivia Masterson (season 1). Formerly the olive girl for the "Langley Olives" company, she was once Zeke's next door neighbor and crush. She tried designing him a skater look in the episode "Cape Fear " but only for it to fail, mainly to a large cape that became a safety hazard. It is noted that she has a crush on Zeke. She did not know that he liked her until the episode "Adventure Boy". She is said to like brave guys.
• Andy Pessoa as Garrett "Stinky Cast" Delfino (seasons 1–2), a local boy who constantly wears the same sleeveless white shirts, jean shorts and trademark cast on his arm. He is Zeke and Luther's camera guy. He has the hugest crush on Ginger which Zeke uses as leverage to pay for Stinky Cast's videos. He had his cast removed in the episode "The Big Red Stacking Machine" which he was upset about due to losing his trademark. He then proceeded to try to injure himself to get a new cast and succeeded, thus restoring his name.
• David Gore as Kirby Cheddar (seasons 1–2). He lives near Zeke and Luther. He plays the airdrums and the trombone. His mother is very overprotective.
• Reid Ewing and Chris Zylka as Charlie and Doyce Plunk (entire run and seasons 1–2, respectively). Brothers that are always ready to give Zeke and Luther a hard time, and they are their archrivals. They come from a family of barbers and they play pranks on other teens by cutting their hairs.
• Davis Cleveland as Roy Waffles (seasons 2–3), Luther's younger and rarely mentioned brother. He is obsessed with playing video games and stays in his room so much that he did not even know what the sun was when Zeke and Luther took him outside. When someone takes his video game away from him, he gets "Roy Rage" and becomes super strong, allowing him to bend metal bars and lift a car. He has appeared in the episodes "Little Bro, Big Trouble" and "Sibling Rivalries".
• Carlos Lacámara as Dr. Ricardo (season 2–3), a doctor that Zeke and Luther regularly visit who sometimes does not give the best prescriptions.
• Paul Tei as Eddie Coletti (season 3), the owner of Riot Skates, the company that Zeke and Luther are sponsored by. He is known to have a major sweating problem.
• Claudia Lee as Bridget (season 3), a waitress at Don's Donuts and Luther's love interest. She is a common-sense person surrounded by crazy characters.

Season 1 premiered on August 15, 2009 in Australia and New Zealand, on September 20, 2009 in Canada, on October 3, 2009 in the United Kingdom and Ireland, on November 15, 2009 in India, and on December 13, 2009 in Singapore, Hong Kong, the Philippines, and Romania.

Season 2 premiered on June 28, 2010 in Australia and New Zealand, on March 12, 2010 in Canada, on September 18, 2010 in the United Kingdom and Ireland, on June 15, 2010 in India, and on April 17, 2011 in Singapore, Hong Kong, the Philippines, and Romania.

Season 3 premiered on February 28, 2011, and ended on April 2, 2012. Season 3 was the series' final season.