(S)-2-hydroxy-fatty-acid dehydrogenase
In enzymology, a (S)-2-hydroxy-fatty-acid dehydrogenase (EC 1.1.1.99) is an enzyme that catalyzes the chemical reaction
- (S)-2-hydroxystearate + NAD+ 2-oxostearate + NADH + H+
| (S)-2-hydroxy-fatty-acid dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.99 | ||||||||
| CAS number | 37250-33-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are (S)-2-hydroxystearate and NAD+, whereas its 3 products are 2-oxostearate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-2-hydroxystearate:NAD+ oxidoreductase. Other names in common use include dehydrogenase, L-2-hydroxy fatty acid, L-2-hydroxy fatty acid dehydrogenase, and 2-hydroxy fatty acid oxidase.
References
- Huang WY, Tang J (1970). "Carboxyl-terminal sequence of human gastricsin and pepsin". J. Biol. Chem. 245 (9): 2189–93. PMID 4909888.
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