AKR1B10

Aldo-keto reductase family 1 member B10 is an enzyme that in humans is encoded by the AKR1B10 gene.[5][6][7]

AKR1B10
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAKR1B10, AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI, aldo-keto reductase family 1, member B10 (aldose reductase), aldo-keto reductase family 1 member B10
External IDsOMIM: 604707 MGI: 107673 HomoloGene: 116462 GeneCards: AKR1B10
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7q33Start134,527,567 bp[1]
End134,541,412 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

57016

14187

Ensembl

ENSG00000198074

ENSMUSG00000029762

UniProt

O60218

P45377

RefSeq (mRNA)

NM_020299

NM_008012

RefSeq (protein)

NP_064695

NP_032038

Location (UCSC)Chr 7: 134.53 – 134.54 MbChr 6: 34.35 – 34.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000198074 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029762 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hyndman DJ, Flynn TG (August 1998). "Sequence and expression levels in human tissues of a new member of the aldo-keto reductase family". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1399 (2–3): 198–202. doi:10.1016/s0167-4781(98)00109-2. PMID 9765596.
  6. Cao D, Fan ST, Chung SS (May 1998). "Identification and characterization of a novel human aldose reductase-like gene". The Journal of Biological Chemistry. 273 (19): 11429–35. doi:10.1074/jbc.273.19.11429. PMID 9565553.
  7. "Entrez Gene: AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)".

Further reading

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Aldo-keto reductase family 1 member B10 (AKR1B10)]
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