(S)-usnate reductase
In enzymology, a (S)-usnate reductase (EC 1.1.1.199) is an enzyme that catalyzes the chemical reaction
- (6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6- methyl-2,4-cyclohexadien-1-one + NAD+ (S)-usnic acid + NADH + H+
| (S)-usnate reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.199 | ||||||||
| CAS number | 77237-99-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In the reverse direction, (S)-usnate is reduced by NADH with cleavage of the ether bond to form a 7-hydroxy group.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is reduced-(S)-usnate:NAD+ oxidoreductase (ether-bond-forming). This enzyme is also called L-usnic acid dehydrogenase.
References
- Barbini N, Gorini G, Ferrucci L, Biggeri A (2005). "[Analysis of arterial hypertension and work in the epidemiologic study "Aging, Health and Work"]". Epidemiol. Prev. 29 (3–4): 160–165. PMID 16454408.
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