10-deacetylbaccatin III 10-O-acetyltransferase

In enzymology, a 10-deacetylbaccatin III 10-O-acetyltransferase (EC 2.3.1.167) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + 10-deacetylbaccatin III CoA + baccatin III
10-deacetylbaccatin III 10-O-acetyltransferase
Identifiers
EC number2.3.1.167
CAS number220946-63-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are acetyl-CoA and 10-deacetylbaccatin III, whereas its two products are CoA and baccatin III.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:taxan-10beta-ol O-acetyltransferase. This enzyme participates in diterpenoid biosynthesis.

References

    • Walker K, Croteau R (2000). "Molecular cloning of a 10-deacetylbaccatin III-10-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli". Proc. Natl. Acad. Sci. U.S.A. 97 (2): 583–7. doi:10.1073/pnas.97.2.583. PMC 15373. PMID 10639122.


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