Citrate (Re)-synthase

In enzymology, a citrate (Re)-synthase (EC 2.3.3.3) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + H2O + oxaloacetate citrate + CoA
citrate (Re)-synthase
Identifiers
EC number2.3.3.3
CAS number9077-70-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

The 3 substrates of this enzyme are acetyl-CoA, H2O, and oxaloacetate, whereas its two products are citrate and CoA.

This enzyme belongs to the family of transferases, specifically those acyltransferases that convert acyl groups into alkyl groups on transfer. The systematic name of this enzyme class is acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-R)-carboxymethyl-forming]. Other names in common use include (R)-citrate synthase, Re-citrate-synthase, and citrate oxaloacetate-lyase [(pro-3R)-CH2COO-->acetyl-CoA].

References

    • Dittbrenner S, Chowdhury AA, Gottschalk G (1969). "The stereospecificity of the (R)-citrates synthase in the presence of p-chloromercuribenzoate". Biochem. Biophys. Res. Commun. 36 (5): 802–8. doi:10.1016/0006-291X(69)90680-9. PMID 5808294.
    • Gottschalk G (1969). "Partial purification and some properties of the (R)-citrate synthase from Clostridium acidi-urici". Eur. J. Biochem. 7 (2): 301–6. doi:10.1111/j.1432-1033.1969.tb19607.x. PMID 4974734.
    • Gottschalk G, Barker HA (1966). "Synthesis of glutamate and citrate by Clostridium kluyveri. A new type of citrate synthase". Biochemistry. 5 (4): 1125–33. doi:10.1021/bi00868a003. PMID 5958189.


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