2000 CAF Champions League

Team 1	Agg.	Team 2	1st leg	2nd leg
Tusker FC	2–2 (6-5 p)	Red Sea FC	1–1	1–1
SC Villa	2–5	Saint George	2–2	0–3
Vital'O FC	5–0	Bata Bullets	4–0	1–0
Dragons de l'Ouémé	3–1	Gambia Ports Authority FC	2–0	1–1
Sporting Praia	2–4	Tempête Mocaf	2–3	0–1
Primeiro de Agosto	5–0	Akonangui	4–0	1–0
Horoya AC	3–1	Sporting Bissau	2–0	1–1
Notwane FC	3–5	Black Africa SC	1–1	2–4
AS de Vacoas-Phoenix	3–21	St.-Michel United	1–1	2–1
AS Fortior	0–0 (2-3 p)	LDF	0–0	0–0
Al Ahli Tripoli	6–1	Olympic Niamey	4–0	2–1
APR FC	2–2 (3-2 p)	Renaissance FC	1–1	1–1
Ferroviário de Maputo	3–3 (a)	Prisons FC	1–0	2–3

¹ AS de Vacoas-Phoenix were ejected from the competition for fielding an ineligible player.

Team 1	Agg.	Team 2	1st leg	2nd leg
Raja Casablanca	5–3	Dragons de l'Ouémé	3–1	2–2
MC Alger	2–6	Jeanne d'Arc	1–1	1–5
Al Ahly	3–2	Tusker FC	3–1	0–1
Saint George	3–4	Vital'O FC	1–2	2–2
ES Tunis	7–0	APR FC	7–0	1
ASFA Yennenga	3–3 (a)	Djoliba AC	2–2	1–1
Lobi Stars	3–1	Tempête Mocaf	2–0	1–1
Vita Club Mokanda	2–5	Primeiro de Agosto	2–1	0–4
Hearts of Oak	4–3	Horoya AC	2–1	2–2
DC Motema Pembe	w/o2	Black Africa SC	–	–
Highlanders FC	3–0	St.-Michel United	1–0	2–0
Sable FC	3–2	FC 105 Libreville	2–1	1–1
US Stade Tamponnaise	1–5	Nkana FC	1–2	0–3
Mamelodi Sundowns	6–2	LDF	2–1	4–1
Africa Sports	6–0	Al Ahli Tripoli	4–0	2–0
Al-Hilal	2–2 (4-5 p)	Ferroviário de Maputo	1–1	1–1

¹ APR FC withdrew after the first leg; they were banned from CAF competitions for three years and fined $4000.
² Black Africa SC withdrew.

2 December 2000

--:-- UTC+1

ES Tunis	1–2	Hearts of Oak
Zitouni  36'		Addo  52' Kuffour  79'

Stade El Menzah, Tunis

Attendance: 30,000

Referee: Lim Kee Chong (Mauritius)

17 December 2000

--:-- UTC±0

Hearts of Oak	3–11	ES Tunis
Kuffour  83', 89' Addo  90'		Gabsi  18'

Ohene Djan Stadium, Accra

Attendance: 45,000

Referee: Robin Williams (South Africa)

¹ The match was interrupted for 18 minutes at 75' with ES Tunis leading 1–0 after teargas was fired into a rioting crowd by police, with one canister landing in the VIP box.ES Tunis protested against the result, but the protest was rejected. It was also marred by the antics of Espérance's goalkeeper Chokri El Ouaer who deliberately injured himself with the intent to get the game abandoned. He was banned for one year by CAF for gamesmanship after the game.