2015–16 Women's EHF Challenge Cup

Teams listed first played the first leg at home. Some teams agreed to play both matches in the same venue. Bolded teams qualified into last 16.

Team 1	Agg.	Team 2	1st leg	2nd leg
IBV Vestmannaeyjar	56–61a	ŽRK Izvor Bukovička Banja	28–30	28–31
ŽRK Danilovgrad	42–52	ŽRK Mlinotest Ajdovščina	24–30	18–22
Colégio de Gaia	68–58b	HIFK	36–29	32–29
ŽRK Pelister	57–77	KHF Shqiponja	22–38	35–39
Izmir BB GSK	54–40	DHB Rotweiss Thun	27–17	27–23
Metraco Zagłębie Lubin	78–29c	Maccabi Arazim Ramat Gan	41–12	37–17
ABU Baku	41–56d	Schuler Afbouwgroep/DOS	19–27	22–29
Yellow Winterthur	59–40	ASD Ariosta P. Ferrara	34–21	25–19
HC Vardar SCJS	62–31e	London Angels HC	27–14	35–17

Notes

Teams listed first played the first leg at home. Some teams agreed to play both matches in the same venue. Teams listed first played the first leg at home. Bolded teams qualified for the semifinals.

Team 1	Agg.	Team 2	1st leg	2nd leg
HC Vardar SCJS	39–47	HC Karpaty	22–19	17–28
EKS Start Elblag	48–46	Izmir BB SK	29–25	19–21
Gran Canaria	62–44a	ŽRK Izvor Bukovička Banja	35–25	27–19
Kastamonu Bld. GSK	52–46b	Virto/Quintus	27–23	25–23

Notes

^a Both legs were hosted by Gran Canaria.

^b Both legs were hosted by Kastamonu Bld. GSK.

Team listed first played the first leg at home.

Team 1	Agg.	Team 2	1st leg	2nd leg
Kastamonu Bld. GSK	54–62	Gran Canaria	25–29	29–33