4-oxoproline reductase
In enzymology, a 4-oxoproline reductase (EC 1.1.1.104) is an enzyme that catalyzes the chemical reaction
- 4-hydroxy-L-proline + NAD+ 4-oxoproline + NADH + H+
| 4-oxoproline reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.104 | ||||||||
| CAS number | 37250-37-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 4-hydroxy-L-proline and NAD+, whereas its 3 products are 4-oxoproline, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-hydroxy-L-proline:NAD+ oxidoreductase. This enzyme is also called hydroxy-L-proline oxidase. This enzyme participates in arginine and proline metabolism.
References
- Smith TE, Mitoma C (April 1962). "Partial purification and some properties of 4-ketoproline reductase". The Journal of Biological Chemistry. 237: 1177–80. PMID 13914427.
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