6-hydroxyhexanoate dehydrogenase
In enzymology, a 6-hydroxyhexanoate dehydrogenase (EC 1.1.1.258) is an enzyme that catalyzes the chemical reaction
- 6-hydroxyhexanoate + NAD+ 6-oxohexanoate + NADH + H+
| 6-hydroxyhexanoate dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.258 | ||||||||
| CAS number | 77000-03-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 6-hydroxyhexanoate and NAD+, whereas its 3 products are 6-oxohexanoate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 6-hydroxyhexanoate:NAD+ oxidoreductase. This enzyme participates in caprolactam degradation.
References
- Donoghue NA, Trudgill PW (1975). "The metabolism of cyclohexanol by Acinetobacter NCIB 9871". Eur. J. Biochem. 60 (1): 1–7. doi:10.1111/j.1432-1033.1975.tb20968.x. PMID 1261.
- Hecker LI, Tondeur Y, Farrelly JG (1984). "Formation of epsilon-hydroxycaproate and epsilon-aminocaproate from N-nitrosohexamethyleneimine: evidence that microsomal alpha-hydroxylation of cyclic nitrosamines may not always involve the insertion of molecular oxygen into the substrate". Chem. Biol. Interact. 49 (1–2): 235–48. doi:10.1016/0009-2797(84)90064-4. PMID 6722936.
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