ADARB1

Double-stranded RNA-specific editase 1 is an enzyme that in humans is encoded by the ADARB1 gene.[5][6][7]

ADARB1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesADARB1, ADAR2, DRABA2, DRADA2, RED1, adenosine deaminase, RNA specific B1, adenosine deaminase RNA specific B1, NEDHYMS
External IDsOMIM: 601218 MGI: 891999 HomoloGene: 8280 GeneCards: ADARB1
Gene location (Human)
Chr.Chromosome 21 (human)[1]
Band21q22.3Start45,073,853 bp[1]
End45,226,560 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

104

110532

Ensembl

ENSG00000197381

ENSMUSG00000020262

UniProt

P78563

Q91ZS8

RefSeq (mRNA)

NM_001024837
NM_001024838
NM_001024839
NM_001024840
NM_130895

RefSeq (protein)

NP_001020008
NP_570965
NP_001020009

Location (UCSC)Chr 21: 45.07 – 45.23 MbChr 10: 77.29 – 77.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rats found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region.[7]

ADARB1 (ADAR2) requires the small molecule inositol hexakisphosphate (IP6) for proper function.[8] ADAR2 is an A-to-I RNA-editing enzyme that mostly acts on protein-coding substrates.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000197381 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020262 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Mittaz L, Scott HS, Rossier C, Seeburg PH, Higuchi M, Antonarakis SE (April 1997). "Cloning of a human RNA editing deaminase (ADARB1) of glutamate receptors that maps to chromosome 21q22.3". Genomics. 41 (2): 210–7. doi:10.1006/geno.1997.4655. PMID 9143496.
  6. Keegan LP, Leroy A, Sproul D, O'Connell MA (Feb 2004). "Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes". Genome Biology. 5 (2): 209. doi:10.1186/gb-2004-5-2-209. PMC 395743. PMID 14759252.
  7. "Entrez Gene: ADARB1 adenosine deaminase, RNA-specific, B1 (RED1 homolog rat)".
  8. Macbeth MR, Schubert HL, Vandemark AP, Lingam AT, Hill CP, Bass BL (September 2005). "Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing". Science. 309 (5740): 1534–9. Bibcode:2005Sci...309.1534M. doi:10.1126/science.1113150. PMC 1850959. PMID 16141067.
  9. Licht K, Jantsch MF (April 2016). "Rapid and dynamic transcriptome regulation by RNA editing and RNA modifications". The Journal of Cell Biology. 213 (1): 15–22. doi:10.1083/jcb.201511041. PMC 4828693. PMID 27044895.

Further reading


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