Dihydroorotase

Dihydroorotase (EC 3.5.2.3, carbamoylaspartic dehydrase, dihydroorotate hydrolase) is an enzyme which converts carbamoyl aspartic acid into 4,5-dihydroorotic acid in the biosynthesis of pyrimidines.[1][2] It forms a multifunctional enzyme with carbamoyl phosphate synthetase and aspartate transcarboymalase.

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Dihydroorotase (fragment) dimer, Human
Identifiers
SymbolCAD
NCBI gene790
HGNC1424
OMIM114010
RefSeqNM_004341
UniProtP27708
Other data
EC number3.5.2.3
LocusChr. 2 p22-p21

See also

References

  1. Cooper C, Wilson DW (1954). "Biosynthesis of pyrimidines". Fed. Proc. 13: 194.
  2. Lieberman I, Kornberg A (April 1954). "Enzymatic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydroortic acid, ureidosuccinic acid, and 5-carboxymethylhydantoin" (PDF). The Journal of Biological Chemistry. 207 (2): 911–24. PMID 13163076.


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