ANAPC7

Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ANAPC7 gene.[5] Multiple transcript variants encoding different isoforms have been found for this gene.

ANAPC7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesANAPC7, APC7, anaphase promoting complex subunit 7
External IDsOMIM: 606949 MGI: 1929711 HomoloGene: 10512 GeneCards: ANAPC7
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q24.11Start110,372,900 bp[1]
End110,403,730 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

51434

56317

Ensembl

ENSG00000196510

ENSMUSG00000029466

UniProt

Q9UJX3

Q9WVM3

RefSeq (mRNA)

NM_001137664
NM_016238

NM_019805

RefSeq (protein)

NP_001131136
NP_057322
NP_057322.2

NP_062779

Location (UCSC)Chr 12: 110.37 – 110.4 MbChr 5: 122.42 – 122.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a tetratricopeptide repeat containing component of the anaphase-promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators.[5]

Interactions

ANAPC7 has been shown to interact with ANAPC1,[6][7] ANAPC4,[6] CDC27[6][8] and CDC20.[6][9]

References

  1. GRCh38: Ensembl release 89: ENSG00000196510 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029466 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: ANAPC7 anaphase promoting complex subunit 7".
  6. Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947. S2CID 5942532.
  7. Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. PMC 2169443. PMID 11076961.
  8. Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056.
  9. Nilsson J, Yekezare M, Minshull J, Pines J (December 2008). "The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction". Nat. Cell Biol. 10 (12): 1411–20. doi:10.1038/ncb1799. PMC 2635557. PMID 18997788.

Further reading


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