ANP32C

Acidic leucine-rich nuclear phosphoprotein 32 family member C is a protein that in humans is encoded by the ANP32C gene.[3][4][5]

ANP32C
Identifiers
AliasesANP32C, PP32R1, acidic nuclear phosphoprotein 32 family member C
External IDsOMIM: 606877 HomoloGene: 49316 GeneCards: ANP32C
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q32.3Start164,197,007 bp[1]
End164,197,711 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

23520

n/a

Ensembl

ENSG00000248546

n/a

UniProt

O43423

n/a

RefSeq (mRNA)

NM_012403

n/a

RefSeq (protein)

NP_036535

n/a

Location (UCSC)Chr 4: 164.2 – 164.2 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Function

Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is divergent between PP32 and the protein encoded by this gene. This gene does not contain introns.[5]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000248546 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Kadkol SS, Brody JR, Pevsner J, Bai J, Pasternack GR (March 1999). "Modulation of oncogenic potential by alternative gene use in human prostate cancer". Nature Medicine. 5 (3): 275–9. doi:10.1038/6488. PMID 10086381. S2CID 24559649.
  4. Brody JR, Kadkol SS, Mahmoud MA, Rebel JM, Pasternack GR (July 1999). "Identification of sequences required for inhibition of oncogene-mediated transformation by pp32". The Journal of Biological Chemistry. 274 (29): 20053–5. doi:10.1074/jbc.274.29.20053. PMID 10400610.
  5. "Entrez Gene: ANP32C acidic (leucine-rich) nuclear phosphoprotein 32 family, member C".

Further reading

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