ANP32E

ANP32E
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4CAY, 4NFT
Identifiers
Aliases	ANP32E, LANP-L, LANPL, acidic nuclear phosphoprotein 32 family member E
External IDs	OMIM: 609611 HomoloGene: 137403 GeneCards: ANP32E
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	150,236,156 bp[1]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• histone binding; • phosphatase inhibitor activity;
Cellular component	• cytoplasm; • cell nucleus; • Swr1 complex; • cytoplasmic vesicle;
Biological process	• GO:0048553 negative regulation of catalytic activity; • histone exchange; • nucleosome assembly; • nucleocytoplasmic transport; • regulation of apoptotic process; • chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	81611
	n/a
	ENSG00000143401
	n/a
	Q9BTT0
	n/a
	NM_001136478; NM_001136479; NM_001280559; NM_001280560; NM_030920
	n/a
	NP_001129950; NP_001129951; NP_001267488; NP_001267489; NP_112182
	n/a
	Wikidata
View/Edit Human

Acidic leucine-rich nuclear phosphoprotein 32 family member E is a protein that in humans is encoded by the ANP32E gene.[3][4] The ANP32E gene is located on chromosome 1q22.[3] In mammalian cells, ANP32E has been shown to be an H2A.Z chaperone capable of promoting the removal of H2A.Z from chromatin.[5] In brain tissue, ANP32E together with Cpd1 regulate protein phosphatase 2A activity at synapses during synaptogenesis[6] and has been observed to form a complex with ANP32A and SET that stabilizes short-lived mRNAs containing AU-rich elements, as well as having acetyltransferase inhibitory activity (in a complex with SET) and having a role in chromatin remodeling and transcriptional regulation.[7]

References

GRCh38: Ensembl release 89: ENSG00000143401 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Jiang M, Ma Y, Ni X, Cao G, Ji C, Cheng H, Tang R, Xie Y, Mao Y (Nov 2002). "Molecular cloning and characterization of a novel human gene (ANP32E alias LANPL) from human fetal brain". Cytogenet Genome Res. 97 (1–2): 68–71. doi:10.1159/000064058. PMID 12438741. S2CID 30549428.
"Entrez Gene: ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E".
Obri A, Ouararhni K, Papin C, Diebold ML, Padmanabhan K, Marek M, Stoll I, Roy L, Reilly PT, Mak TW, Dimitrov S, Romier C, Hamiche A (2014). "ANP32E is a histone chaperone that removes H2A.Z from chromatin". Nature. 505 (7485): 648–53. Bibcode:2014Natur.505..648O. doi:10.1038/nature12922. PMID 24463511. S2CID 4406370.
Costanzo RV, Vilá-Ortíz GJ, Perandones C, Carminatti H, Matilla A, Radrizzani M (2006). "Anp32e/Cpd1 regulates protein phosphatase 2A activity at synapses during synaptogenesis". Eur. J. Neurosci. 23 (2): 309–24. doi:10.1111/j.1460-9568.2005.04555.x. PMID 16420440. S2CID 46587416.
Santa-Coloma TA (2003). "Anp32e (Cpd1) and related protein phosphatase 2 inhibitors". Cerebellum. 2 (4): 310–20. doi:10.1080/14734220310017212. PMID 14964690. S2CID 21454532.

External links

Human ANP32E genome location and ANP32E gene details page in the UCSC Genome Browser.

Matilla A, Radrizzani M (2005). "The Anp32 family of proteins containing leucine-rich repeats". Cerebellum. 4 (1): 7–18. doi:10.1080/14734220410019020. PMID 15895553. S2CID 39153579.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143401 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12438741-3] Jiang M, Ma Y, Ni X, Cao G, Ji C, Cheng H, Tang R, Xie Y, Mao Y (Nov 2002). "Molecular cloning and characterization of a novel human gene (ANP32E alias LANPL) from human fetal brain". Cytogenet Genome Res. 97 (1–2): 68–71. doi:10.1159/000064058. PMID 12438741. S2CID 30549428.

[entrez-4] "Entrez Gene: ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E".

[pmid24463511-5] Obri A, Ouararhni K, Papin C, Diebold ML, Padmanabhan K, Marek M, Stoll I, Roy L, Reilly PT, Mak TW, Dimitrov S, Romier C, Hamiche A (2014). "ANP32E is a histone chaperone that removes H2A.Z from chromatin". Nature. 505 (7485): 648–53. Bibcode:2014Natur.505..648O. doi:10.1038/nature12922. PMID 24463511. S2CID 4406370.

[pmid16420440-6] Costanzo RV, Vilá-Ortíz GJ, Perandones C, Carminatti H, Matilla A, Radrizzani M (2006). "Anp32e/Cpd1 regulates protein phosphatase 2A activity at synapses during synaptogenesis". Eur. J. Neurosci. 23 (2): 309–24. doi:10.1111/j.1460-9568.2005.04555.x. PMID 16420440. S2CID 46587416.

[pmid14964690-7] Santa-Coloma TA (2003). "Anp32e (Cpd1) and related protein phosphatase 2 inhibitors". Cerebellum. 2 (4): 310–20. doi:10.1080/14734220310017212. PMID 14964690. S2CID 21454532.

ANP32E

See also

References

External links

Further reading