ATP12A

ATP12A
Identifiers
Aliases	ATP12A, ATP1AL1, #945, HK, ATPase H+/K+ transporting non-gastric alpha2 subunit, H-K-ATPase
External IDs	OMIM: 182360 MGI: 1926943 HomoloGene: 68197 GeneCards: ATP12A
Gene location (Human)
Chr.	Chromosome 13 (human)[1]
End	24,712,493 bp[1]
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)[2]
End	56,388,550 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• nucleotide binding; • metal ion binding; • cation-transporting ATPase activity; • hydrolase activity; • ATP binding; • sodium:potassium-exchanging ATPase activity; • hydrogen:potassium-exchanging ATPase activity; • potassium-transporting ATPase activity;
Cellular component	• integral component of membrane; • membrane; • cell membrane; • basolateral plasma membrane; • H(+)/K(+)-exchanging ATPase;
Biological process	• sodium ion transport; • ion transport; • potassium ion transport; • potassium ion homeostasis; • regulation of pH; • establishment or maintenance of transmembrane electrochemical gradient; • hydrogen ion transmembrane transport; • cellular sodium ion homeostasis; • cellular potassium ion homeostasis; • sodium ion export from cell; • potassium ion import across plasma membrane; • ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	479
	192113
	ENSG00000075673
	ENSMUSG00000022229
	P54707
	Q9Z1W8
	NM_001676; NM_001185085
	NM_138652
	NP_001172014; NP_001667
	NP_619593
	Wikidata
View/Edit Human	View/Edit Mouse

ATPase, H+/K+ transporting, nongastric, alpha polypeptide (also known as ATP12A) is a protein that in humans is encoded by the ATP12A gene.[5][6][7]

Function

The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H⁺/K⁺ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H⁺ and K⁺ ions across the plasma membrane. It is also responsible for potassium absorption in various tissues.[5]

References

GRCh38: Ensembl release 89: ENSG00000075673 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022229 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide".
Sverdlov VE, Kostina MB, Modyanov NN (March 1996). "Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase". Genomics. 32 (3): 317–27. doi:10.1006/geno.1996.0125. PMID 8838794.
Yang-Feng TL, Schneider JW, Lindgren V, Shull MM, Benz EJ, Lingrel JB, Francke U (February 1988). "Chromosomal localization of human Na⁺, K⁺-ATPase alpha- and beta-subunit genes". Genomics. 2 (2): 128–38. doi:10.1016/0888-7543(88)90094-8. PMID 2842249.

External links

Human ATP12A genome location and ATP12A gene details page in the UCSC Genome Browser.

Modyanov NN, Petrukhin KE, Sverdlov VE, et al. (1991). "The family of human Na,K-ATPase genes. ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase". FEBS Lett. 278 (1): 91–4. doi:10.1016/0014-5793(91)80091-G. PMID 1847115.
Yang-Feng TL, Schneider JW, Lindgren V, et al. (1988). "Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes". Genomics. 2 (2): 128–38. doi:10.1016/0888-7543(88)90094-8. PMID 2842249.
Shull MM, Lingrel JB (1987). "Multiple genes encode the human Na+,K+-ATPase catalytic subunit". Proc. Natl. Acad. Sci. U.S.A. 84 (12): 4039–43. doi:10.1073/pnas.84.12.4039. PMC 305017. PMID 3035563.
Sverdlov ED, Monastyrskaya GS, Broude NE, et al. (1987). "The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit". FEBS Lett. 217 (2): 275–8. doi:10.1016/0014-5793(87)80677-4. PMID 3036582.
Grishin AV, Sverdlov VE, Kostina MB, Modyanov NN (1994). "Cloning and characterization of the entire cDNA encoded by ATP1AL1--a member of the human Na,K/H,K-ATPase gene family". FEBS Lett. 349 (1): 144–50. doi:10.1016/0014-5793(94)00655-5. PMID 8045293.
Sverdlov VE, Kostina MB, Modyanov NN (1997). "Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase". Genomics. 32 (3): 317–27. doi:10.1006/geno.1996.0125. PMID 8838794.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Pestov NB, Romanova LG, Korneenko TV, et al. (1999). "Ouabain-sensitive H,K-ATPase: tissue-specific expression of the mammalian genes encoding the catalytic alpha subunit". FEBS Lett. 440 (3): 320–4. doi:10.1016/S0014-5793(98)01483-5. PMID 9872395.
Pestov NB, Korneenko TV, Adams G, et al. (2002). "Nongastric H-K-ATPase in rodent prostate: lobe-specific expression and apical localization". Am. J. Physiol., Cell Physiol. 282 (4): C907–16. doi:10.1152/ajpcell.00258.2001. PMID 11880279.
Reinhardt J, Kosch M, Lerner M, et al. (2002). "Stimulation of protein kinase C pathway mediates endocytosis of human nongastric H+-K+-ATPase, ATP1AL1". Am. J. Physiol. Renal Physiol. 283 (2): F335–43. doi:10.1152/ajprenal.00226.2001. PMID 12110518.
Takahashi Y, Sakai H, Kuragari M, et al. (2003). "Expression of ATP1AL1, a non-gastric proton pump, in human colorectum". Jpn. J. Physiol. 52 (3): 317–21. doi:10.2170/jjphysiol.52.317. PMID 12230809.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Li J, Codina J, Petroske E, et al. (2004). "The carboxy terminus of the colonic H(+), K(+)-ATPase alpha-subunit is required for stable beta subunit assembly and function". Kidney Int. 65 (4): 1301–10. doi:10.1111/j.1523-1755.2004.00507.x. PMID 15086469.
Johansson M, Jansson T, Pestov NB, Powell TL (2004). "Non-gastric H+/K+ ATPase is present in the microvillous membrane of the human placental syncytiotrophoblast". Placenta. 25 (6): 505–11. doi:10.1016/j.placenta.2003.11.008. PMID 15135233.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000075673 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022229 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide".

[pmid8838794-6] Sverdlov VE, Kostina MB, Modyanov NN (March 1996). "Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase". Genomics. 32 (3): 317–27. doi:10.1006/geno.1996.0125. PMID 8838794.

[pmid2842249-7] Yang-Feng TL, Schneider JW, Lindgren V, Shull MM, Benz EJ, Lingrel JB, Francke U (February 1988). "Chromosomal localization of human Na⁺, K⁺-ATPase alpha- and beta-subunit genes". Genomics. 2 (2): 128–38. doi:10.1016/0888-7543(88)90094-8. PMID 2842249.

ATP12A

Function

References

External links

Further reading