Abducens nucleus

Two primary neuron types are located in the abducens nucleus: motorneurons and interneurons. The former directly drive the contraction of the ipsilateral lateral rectus muscle via the abducens nerve (sixth cranial nerve); contraction of this muscle rotates the eye outward (abduction). The latter relay signals from the abducens nucleus to the contralateral oculomotor nucleus, where motoneurons drive the contraction of the ipsilateral medial rectus muscle (hence, contralateral to the abducens nucleus that issues the command) ; contraction of this muscle rotates the eye inward (adduction).

This "wiring" pattern suggests that the main function of the abducens nucleus is to generate coordinated movements of both eyes in the same direction. Indeed, electrical stimulation of the abducens nucleus has been shown to generate conjugate eye movements (i.e. both eyes rotate in the same direction, and by the same angle). Such eye movements occur whenever we look between targets located in the distance. Moreover, lesions to the axonal tract of interneurons (in the medial longitudinal fasciculus) have been shown to disrupt conjugate eye movements through the paralysis of the contralateral eye. Importantly, despite the lesions, this muscle remains functional during convergence eye movements. Finally, experiments where the electrical activity of single neurons in the abducens nucleus has been recorded during slow and fast conjugate eye movements have demonstrated very little differences in the discharge patterns of motoneurons and interneurons.

Altogether, it is now well accepted that the abducens nucleus is a key structure for the conjugated movements of both eyes.

Damage to the abducens nerve causes monocular ipsilateral lateral ophthalmoparesis: specifically, loss of the ability to move the ipsilateral eye outward (abduction).

In contrast, damage to the area of the nucleus results in binocular lateral gaze paralysis: loss of the ability to move the eyes together in the direction of the side with the lesion. This is due to damage to both the motoneurons and interneurons projecting through the medial longitudinal fasciculus to the contralateral medial rectus neurons. Note, however, that the eye contralateral to the lesion can still move in the direction of the lesion during convergence movements.

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  Nuclei of origin of cranial motor nerves schematically represented; lateral view.
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  Scheme showing central connections of the optic nerves and optic tracts.
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  Figure showing the mode of innervation of the Recti medialis and lateralis of the eye.
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  Axial section of the Brainstem (Pons) at the level of the Facial Colliculus
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  Vestibulo-ocular reflex
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  Brain stem sagittal section
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  Section through lower pons. Abducens nucleus is labeled #4.

• MedEd at Loyola Neuro/frames/nlBSs/nl27fr.htm
• Template (look for "GSE")
• Stained brain slice images which include the "Abducens nucleus" at the BrainMaps project
• NIF Search - Abducens Nucleus via the Neuroscience Information Framework