Alcohol dehydrogenase (nicotinoprotein)

Alcohol dehydrogenase (nicotinoprotein) (EC 1.1.99.36, NDMA-dependent alcohol dehydrogenase, nicotinoprotein alcohol dehydrogenase, np-ADH, ethanol:N,N-dimethyl-4-nitrosoaniline oxidoreductase) is an enzyme with systematic name ethanol:acceptor oxidoreductase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

ethanol + acceptor acetaldehyde + reduced acceptor
Alcohol dehydrogenase (nicotinoprotein)
Identifiers
EC number1.1.99.36
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme contains Zn2+.

References
  1. Van Ophem PW, Van Beeumen J, Duine JA (March 1993). "Nicotinoprotein [NAD(P)-containing] alcohol/aldehyde oxidoreductases. Purification and characterization of a novel type from Amycolatopsis methanolica". European Journal of Biochemistry. 212 (3): 819–26. doi:10.1111/j.1432-1033.1993.tb17723.x. PMID 8385013.
  2. Piersma SR, Visser AJ, de Vries S, Duine JA (March 1998). "Optical spectroscopy of nicotinoprotein alcohol dehydrogenase from Amycolatopsis methanolica: a comparison with horse liver alcohol dehydrogenase and UDP-galactose epimerase". Biochemistry. 37 (9): 3068–77. doi:10.1021/bi972115u. PMID 9485460.
  3. Schenkels P, Duine JA (April 2000). "Nicotinoprotein (NADH-containing) alcohol dehydrogenase from Rhodococcus erythropolis DSM 1069: an efficient catalyst for coenzyme-independent oxidation of a broad spectrum of alcohols and the interconversion of alcohols and aldehydes". Microbiology. 146 ( Pt 4) (4): 775–85. doi:10.1099/00221287-146-4-775. PMID 10784035.
  4. Piersma SR, Norin A, de Vries S, Jörnvall H, Duine JA (July 2003). "Inhibition of nicotinoprotein (NAD+-containing) alcohol dehydrogenase by trans-4-(N,N-dimethylamino)-cinnamaldehyde binding to the active site". Journal of Protein Chemistry. 22 (5): 457–61. doi:10.1023/b:jopc.0000005461.53788.ee. PMID 14690248.
  5. Norin A, Piersma SR, Duine JA, Jörnvall H (May 2003). "Nicotinoprotein (NAD+ -containing) alcohol dehydrogenase: structural relationships and functional interpretations". Cellular and Molecular Life Sciences. 60 (5): 999–1006. doi:10.1007/s00018-003-3105-9. PMID 12827287.
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