Aldehyde dehydrogenase 9 family, member A1

4-trimethylaminobutyraldehyde dehydrogenase is an enzyme that in humans is encoded by the ALDH9A1 gene.[5][6][7]

ALDH9A1
Identifiers
AliasesALDH9A1, ALDH4, ALDH7, ALDH9, E3, TMABADH, aldehyde dehydrogenase 9 family member A1, TMABA-DH, TMABALDH
External IDsOMIM: 602733 MGI: 1861622 HomoloGene: 55483 GeneCards: ALDH9A1
EC number1.2.1.3
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q24.1Start165,662,216 bp[1]
End165,698,863 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

223

56752

Ensembl

ENSG00000143149

ENSMUSG00000026687

UniProt

P49189

Q9JLJ2

RefSeq (mRNA)

NM_000696
NM_001365774

NM_019993

RefSeq (protein)

NP_000687
NP_001352703

NP_064377

Location (UCSC)Chr 1: 165.66 – 165.7 MbChr 1: 167.35 – 167.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000143149 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026687 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. McPherson JD, Wasmuth JJ, Kurys G, Pietruszko R (February 1994). "Human aldehyde dehydrogenase: chromosomal assignment of the gene for the isozyme that metabolizes gamma-aminobutyraldehyde". Human Genetics. 93 (2): 211–2. doi:10.1007/bf00210615. PMID 8112751. S2CID 26773065.
  6. Lin SW, Chen JC, Hsu LC, Hsieh CL, Yoshida A (June 1996). "Human gamma-aminobutyraldehyde dehydrogenase (ALDH9): cDNA sequence, genomic organization, polymorphism, chromosomal localization, and tissue expression". Genomics. 34 (3): 376–80. doi:10.1006/geno.1996.0300. PMID 8786138.
  7. "Entrez Gene: ALDH9A1 aldehyde dehydrogenase 9 family, member A1".

Further reading


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