BUB1B

BUB1B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2WVI, 3SI5, 4GGD, 5JJA
Identifiers
Aliases	BUB1B, BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1, BUB1 mitotic checkpoint serine/threonine kinase B
External IDs	OMIM: 602860 MGI: 1333889 HomoloGene: 933 GeneCards: BUB1B
Gene location (Human)
Chr.	Chromosome 15 (human)[1]
End	40,221,136 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	118,641,591 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• protein serine/threonine kinase activity; • ATP binding; • GO:0001948 protein binding; • kinase activity; • nucleotide binding; • transferase activity; • protein kinase activity;
Cellular component	• kinetochore; • cell nucleus; • cytoskeleton; • condensed chromosome outer kinetochore; • microtubule organizing center; • perinuclear region of cytoplasm; • chromosome, centromeric region; • anaphase-promoting complex; • chromosome; • condensed chromosome kinetochore; • cytoplasm; • spindle midzone; • cytosol; • condensed nuclear chromosome kinetochore; • spindle;
Biological process	• protein localization to chromosome, centromeric region; • anaphase-promoting complex-dependent catabolic process; • mitotic cell cycle checkpoint; • protein phosphorylation; • metaphase/anaphase transition of mitotic cell cycle; • cell cycle; • apoptotic process; • phosphorylation; • cell division; • cellular proliferation; • protein localization to kinetochore; • mitotic spindle assembly checkpoint; • meiotic sister chromatid cohesion, centromeric; • GO:0007067 mitotic cell cycle; • regulation of mitotic cell cycle phase transition; • ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	701
	12236
	ENSG00000156970
	ENSMUSG00000040084
	O60566
	Q9Z1S0
	NM_001211
	NM_009773
	NP_001202
	NP_033903
	Wikidata
View/Edit Human	View/Edit Mouse

Mitotic checkpoint serine/threonine-protein kinase BUB1 beta is an enzyme that in humans is encoded by the BUB1B gene.[5]

Function

This gene encodes a kinase involved in spindle checkpoint function and chromosome segregation.[6] The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.[7]

Increased expression of BubR1 in mice extends a healthy lifespan.[8]

Interactions

BUB1B has been shown to interact with:

AP2B1,[9]
BRCA2[10]
BUB3,[9][11][12]
CDC20,[13][14][15][16][17][18]
HDAC1,[19]
MAD2L1,[13] and
SNCG.[20]

References

GRCh38: Ensembl release 89: ENSG00000156970 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000040084 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Davenport JW, Fernandes ER, Harris LD, Neale GA, Goorha R (March 1999). "The mouse mitotic checkpoint gene bub1b, a novel bub1 family member, is expressed in a cell cycle-dependent manner". Genomics. 55 (1): 113–7. doi:10.1006/geno.1998.5629. PMID 9889005.
Guo Y, Kim C, Ahmad S, Zhang J, Mao Y (July 2012). "CENP-E--dependent BubR1 autophosphorylation enhances chromosome alignment and the mitotic checkpoint". J. Cell Biol. 198 (2): 205–217. doi:10.1083/jcb.201202152. PMC 3410423. PMID 22801780.
"Entrez Gene: BUB1B BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast)".
Baker DJ, Dawlaty MM, Wijshake T, Jeganathan KB, Malureanu L, van Ree JH, Crespo-Diaz R, Reyes S, Seaburg L, Shapiro V, Behfar A, Terzic A, van de Sluis B, van Deursen JM (December 2012). "Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan". Nat. Cell Biol. 15 (1): 96–102. doi:10.1038/ncb2643. PMC 3707109. PMID 23242215. Lay summary – Mayo Clinic.
Cayrol C, Cougoule C, Wright M (November 2002). "The beta2-adaptin clathrin adaptor interacts with the mitotic checkpoint kinase BubR1". Biochem. Biophys. Res. Commun. 298 (5): 720–30. doi:10.1016/S0006-291X(02)02522-6. PMID 12419313.
Futamura M, Arakawa H, Matsuda K, Katagiri T, Saji S, Miki Y, Nakamura Y (March 2000). "Potential role of BRCA2 in a mitotic checkpoint after phosphorylation by hBUBR1". Cancer Res. 60 (6): 1531–5. PMID 10749118.
Hoyt MA (September 2001). "A new view of the spindle checkpoint". J. Cell Biol. 154 (5): 909–11. doi:10.1083/jcb.200108010. PMC 2196198. PMID 11535614.
Taylor SS, Ha E, McKeon F (July 1998). "The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase". J. Cell Biol. 142 (1): 1–11. doi:10.1083/jcb.142.1.1. PMC 2133037. PMID 9660858.
Sudakin V, Chan GK, Yen TJ (September 2001). "Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2". J. Cell Biol. 154 (5): 925–36. doi:10.1083/jcb.200102093. PMC 2196190. PMID 11535616.
Fang G (March 2002). "Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex". Mol. Biol. Cell. 13 (3): 755–66. doi:10.1091/mbc.01-09-0437. PMC 99596. PMID 11907259.
Wu H, Lan Z, Li W, Wu S, Weinstein J, Sakamoto KM, Dai W (September 2000). "p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase". Oncogene. 19 (40): 4557–62. doi:10.1038/sj.onc.1203803. PMID 11030144.
Kallio MJ, Beardmore VA, Weinstein J, Gorbsky GJ (September 2002). "Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells". J. Cell Biol. 158 (5): 841–7. doi:10.1083/jcb.200201135. PMC 2173153. PMID 12196507.
Skoufias DA, Andreassen PR, Lacroix FB, Wilson L, Margolis RL (April 2001). "Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints". Proc. Natl. Acad. Sci. U.S.A. 98 (8): 4492–7. doi:10.1073/pnas.081076898. PMC 31862. PMID 11274370.
Nilsson J, Yekezare M, Minshull J, Pines J (December 2008). "The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction". Nat. Cell Biol. 10 (12): 1411–20. doi:10.1038/ncb1799. PMC 2635557. PMID 18997788.
Yoon YM, Baek KH, Jeong SJ, Shin HJ, Ha GH, Jeon AH, Hwang SG, Chun JS, Lee CW (September 2004). "WD repeat-containing mitotic checkpoint proteins act as transcriptional repressors during interphase". FEBS Lett. 575 (1–3): 23–9. doi:10.1016/j.febslet.2004.07.089. ISSN 0014-5793. PMID 15388328.
Gupta A, Inaba S, Wong OK, Fang G, Liu J (October 2003). "Breast cancer-specific gene 1 interacts with the mitotic checkpoint kinase BubR1". Oncogene. 22 (48): 7593–9. doi:10.1038/sj.onc.1206880. PMID 14576821.

External links

Human BUB1B genome location and BUB1B gene details page in the UCSC Genome Browser.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000156970 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040084 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9889005-5] Davenport JW, Fernandes ER, Harris LD, Neale GA, Goorha R (March 1999). "The mouse mitotic checkpoint gene bub1b, a novel bub1 family member, is expressed in a cell cycle-dependent manner". Genomics. 55 (1): 113–7. doi:10.1006/geno.1998.5629. PMID 9889005.

[pmid22801780-6] Guo Y, Kim C, Ahmad S, Zhang J, Mao Y (July 2012). "CENP-E--dependent BubR1 autophosphorylation enhances chromosome alignment and the mitotic checkpoint". J. Cell Biol. 198 (2): 205–217. doi:10.1083/jcb.201202152. PMC 3410423. PMID 22801780.

[entrez-7] "Entrez Gene: BUB1B BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast)".

[pmid23242215-8] Baker DJ, Dawlaty MM, Wijshake T, Jeganathan KB, Malureanu L, van Ree JH, Crespo-Diaz R, Reyes S, Seaburg L, Shapiro V, Behfar A, Terzic A, van de Sluis B, van Deursen JM (December 2012). "Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan". Nat. Cell Biol. 15 (1): 96–102. doi:10.1038/ncb2643. PMC 3707109. PMID 23242215. Lay summary – Mayo Clinic.

[pmid12419313-9] Cayrol C, Cougoule C, Wright M (November 2002). "The beta2-adaptin clathrin adaptor interacts with the mitotic checkpoint kinase BubR1". Biochem. Biophys. Res. Commun. 298 (5): 720–30. doi:10.1016/S0006-291X(02)02522-6. PMID 12419313.

[pmid10749118-10] Futamura M, Arakawa H, Matsuda K, Katagiri T, Saji S, Miki Y, Nakamura Y (March 2000). "Potential role of BRCA2 in a mitotic checkpoint after phosphorylation by hBUBR1". Cancer Res. 60 (6): 1531–5. PMID 10749118.

[pmid11535614-11] Hoyt MA (September 2001). "A new view of the spindle checkpoint". J. Cell Biol. 154 (5): 909–11. doi:10.1083/jcb.200108010. PMC 2196198. PMID 11535614.

[pmid9660858-12] Taylor SS, Ha E, McKeon F (July 1998). "The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase". J. Cell Biol. 142 (1): 1–11. doi:10.1083/jcb.142.1.1. PMC 2133037. PMID 9660858.

[pmid11535616-13] Sudakin V, Chan GK, Yen TJ (September 2001). "Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2". J. Cell Biol. 154 (5): 925–36. doi:10.1083/jcb.200102093. PMC 2196190. PMID 11535616.

[pmid11907259-14] Fang G (March 2002). "Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex". Mol. Biol. Cell. 13 (3): 755–66. doi:10.1091/mbc.01-09-0437. PMC 99596. PMID 11907259.

[pmid11030144-15] Wu H, Lan Z, Li W, Wu S, Weinstein J, Sakamoto KM, Dai W (September 2000). "p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase". Oncogene. 19 (40): 4557–62. doi:10.1038/sj.onc.1203803. PMID 11030144.

[pmid12196507-16] Kallio MJ, Beardmore VA, Weinstein J, Gorbsky GJ (September 2002). "Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells". J. Cell Biol. 158 (5): 841–7. doi:10.1083/jcb.200201135. PMC 2173153. PMID 12196507.

[pmid11274370-17] Skoufias DA, Andreassen PR, Lacroix FB, Wilson L, Margolis RL (April 2001). "Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints". Proc. Natl. Acad. Sci. U.S.A. 98 (8): 4492–7. doi:10.1073/pnas.081076898. PMC 31862. PMID 11274370.

[pmid18997788-18] Nilsson J, Yekezare M, Minshull J, Pines J (December 2008). "The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction". Nat. Cell Biol. 10 (12): 1411–20. doi:10.1038/ncb1799. PMC 2635557. PMID 18997788.

[pmid15388328-19] Yoon YM, Baek KH, Jeong SJ, Shin HJ, Ha GH, Jeon AH, Hwang SG, Chun JS, Lee CW (September 2004). "WD repeat-containing mitotic checkpoint proteins act as transcriptional repressors during interphase". FEBS Lett. 575 (1–3): 23–9. doi:10.1016/j.febslet.2004.07.089. ISSN 0014-5793. PMID 15388328.

[pmid14576821-20] Gupta A, Inaba S, Wong OK, Fang G, Liu J (October 2003). "Breast cancer-specific gene 1 interacts with the mitotic checkpoint kinase BubR1". Oncogene. 22 (48): 7593–9. doi:10.1038/sj.onc.1206880. PMID 14576821.

BUB1B

Function

Interactions

References

Further reading

External links