Gamma-synuclein

Gamma-synuclein is a protein that in humans is encoded by the SNCG gene.[5][6][7]

SNCG
Identifiers
AliasesSNCG, BCSG1, SR, synuclein gamma
External IDsOMIM: 602998 MGI: 1298397 HomoloGene: 2322 GeneCards: SNCG
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10q23.2Start86,958,599 bp[1]
End86,963,258 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6623

20618

Ensembl

ENSG00000173267

ENSMUSG00000023064

UniProt

O76070

Q9Z0F7

RefSeq (mRNA)

NM_003087
NM_001330120

NM_011430

RefSeq (protein)

NP_001317049
NP_003078

NP_035560

Location (UCSC)Chr 10: 86.96 – 86.96 MbChr 14: 34.37 – 34.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Synuclein-gamma is a member of the synuclein family of proteins, which are believed to be involved in the pathogenesis of neurodegenerative diseases. High levels of SNCG have been identified in advanced breast carcinomas suggesting a correlation between overexpression of SNCG and breast tumor development.[7] Gamma-synuclein is a synuclein protein found primarily in the peripheral nervous system (in primary sensory neurons, sympathetic neurons, and motor neurons) and retina.[8] It is also detected in the brain, ovarian tumors, and in the olfactory epithelium. Gamma-synuclein is the least conserved of the synuclein proteins.[9]

Gamma-Synucleins expression in breast tumors is a marker for tumor progression[10] as mammalian gamma-synuclein was first identified as breast cancer-specific gene 1 (BCSG1). A change in the expression of gamma-synuclein has been observed in the retina of patients with Alzheimer's disease. The normal cellular function of gamma-synuclein remains unknown.[8]

Interactions

Gamma-synuclein has been shown to interact with BUB1B.[11]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000173267 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000023064 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ji H, Liu YE, Jia T, Wang M, Liu J, Xiao G, Joseph BK, Rosen C, Shi YE (Mar 1997). "Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing". Cancer Res. 57 (4): 759–64. PMID 9044857.
  6. Ninkina NN, Alimova-Kost MV, Paterson JW, Delaney L, Cohen BB, Imreh S, Gnuchev NV, Davies AM, Buchman VL (Oct 1998). "Organization, expression and polymorphism of the human persyn gene". Hum Mol Genet. 7 (9): 1417–24. doi:10.1093/hmg/7.9.1417. PMID 9700196.
  7. "Entrez Gene: SNCG synuclein, gamma (breast cancer-specific protein 1)".
  8. George JM (2002). "The synucleins". Genome Biology. 3 (1): REVIEWS3002. doi:10.1186/gb-2001-3-1-reviews3002. PMC 150459. PMID 11806835.
  9. Lavedan C (1998). "The synuclein family". Genome Res. 8 (9): 871–880. doi:10.1101/gr.8.9.871. PMID 9750188.
  10. Bruening W, Giasson BI, Klein-Szanto AJ, Lee VM, Trojanowski JQ, Godwin A (2000). "Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary". Cancer. 88 (9): 2154–2163. doi:10.1002/(SICI)1097-0142(20000501)88:9<2154::AID-CNCR23>3.0.CO;2-9. PMID 10813729.
  11. Gupta, Anu; Inaba Satoru; Wong Oi Kwan; Fang Guowei; Liu Jingwen (Oct 2003). "Breast cancer-specific gene 1 interacts with the mitotic checkpoint kinase BubR1". Oncogene. England. 22 (48): 7593–9. doi:10.1038/sj.onc.1206880. ISSN 0950-9232. PMID 14576821.

Further reading

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