CDK5R1

CDK5R1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1H4L, 1UNG, 1UNH, 1UNL, 3O0G
Identifiers
Aliases	CDK5R1, CDK5P35, CDK5R, NCK5A, p23, p25, p35, p35nck5a, cyclin-dependent kinase 5, regulatory subunit 1 (p35), cyclin dependent kinase 5 regulatory subunit 1
External IDs	OMIM: 603460 MGI: 101764 HomoloGene: 31200 GeneCards: CDK5R1
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	32,491,253 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	80,481,184 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• protein kinase activity; • calcium ion binding; • ephrin receptor binding; • cadherin binding; • GO:0016534 cyclin-dependent protein serine/threonine kinase activator activity; • kinase activity; • GO:0001948 protein binding; • protein kinase binding; • protein serine/threonine kinase activator activity; • protease binding; • actin binding; • ionotropic glutamate receptor binding; • alpha-tubulin binding; • beta-tubulin binding; • actin filament binding; • protein kinase activator activity;
Cellular component	• cytoplasm; • cytosol; • membrane; • GO:0097483, GO:0097481 postsynaptic density; • intracellular membrane-bounded organelle; • growth cone; • neuromuscular junction; • dendritic spine; • axon; • neuronal cell body; • dendrite; • cyclin-dependent protein kinase 5 holoenzyme complex; • perinuclear region of cytoplasm; • contractile fiber; • cell nucleus; • nucleoplasm; • cell membrane; • microtubules; • neuron projection; • presynapse;
Biological process	• positive regulation of protein kinase activity; • regulation of neuron differentiation; • G-protein coupled acetylcholine receptor signaling pathway; • regulation of cyclin-dependent protein serine/threonine kinase activity; • regulation of actin cytoskeleton organization; • embryo development; • rhythmic process; • ephrin receptor signaling pathway; • neuron cell-cell adhesion; • regulation of microtubule cytoskeleton organization; • neuron migration; • cerebellum development; • positive regulation of protein serine/threonine kinase activity; • positive regulation of neuron apoptotic process; • brain development; • ionotropic glutamate receptor signaling pathway; • layer formation in cerebral cortex; • peptidyl-serine phosphorylation; • neuron differentiation; • cellular proliferation; • peptidyl-threonine phosphorylation; • negative regulation of transcription, DNA-templated; • neuron projection development; • cerebral cortex radially oriented cell migration; • axonal fasciculation; • hippocampus development; • negative regulation of axon extension; • regulation of dendritic spine morphogenesis; • regulation of macroautophagy; • superior olivary nucleus maturation; • positive regulation of cell cycle arrest; • positive regulation of protein targeting to membrane; • axon guidance; • regulation of signal transduction by p53 class mediator; • serine phosphorylation of STAT protein; • microtubule cytoskeleton organization; • embryo development ending in birth or egg hatching; • positive regulation of microtubule polymerization; • positive regulation of cyclin-dependent protein serine/threonine kinase activity; • regulation of synaptic vesicle cycle; • activation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	8851
	12569
	ENSG00000176749
	ENSMUSG00000048895
	Q15078
	P61809
	NM_003885
	NM_009871
	NP_003876
	NP_034001
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin-dependent kinase 5 activator 1 is an enzyme that in humans is encoded by the CDK5R1 gene.[5][6]

Function

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.[6]

In melanocytic cells CDK5R1 gene expression may be regulated by MITF.[7]

Interactions

CDK5R1 has been shown to interact with:

References

GRCh38: Ensembl release 89: ENSG00000176749 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000048895 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Tsai LH, Delalle I, Caviness VS Jr, Chae T, Harlow E (October 1994). "p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5". Nature. 371 (6496): 419–23. doi:10.1038/371419a0. PMID 8090221. S2CID 4267944.
"Entrez Gene: CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)".
Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.
Cheng K, Li Z, Fu WY, Wang JH, Fu AK, Ip NY (August 2002). "Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35". J. Biol. Chem. 277 (35): 31988–93. doi:10.1074/jbc.M201161200. PMID 12084709.
Floyd SR, Porro EB, Slepnev VI, Ochoa GC, Tsai LH, De Camilli P (March 2001). "Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2". J. Biol. Chem. 276 (11): 8104–10. doi:10.1074/jbc.M008932200. PMID 11113134.
Kesavapany S, Lau KF, McLoughlin DM, Brownlees J, Ackerley S, Leigh PN, Shaw CE, Miller CC (January 2001). "p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interaction". Eur. J. Neurosci. 13 (2): 241–7. doi:10.1046/j.1460-9568.2001.01376.x. PMID 11168528.
Dhavan R, Greer PL, Morabito MA, Orlando LR, Tsai LH (September 2002). "The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner". J. Neurosci. 22 (18): 7879–91. doi:10.1523/JNEUROSCI.22-18-07879.2002. PMC 6758084. PMID 12223541.
Wang X, Ching YP, Lam WH, Qi Z, Zhang M, Wang JH (October 2000). "Identification of a common protein association region in the neuronal Cdk5 activator". J. Biol. Chem. 275 (41): 31763–9. doi:10.1074/jbc.M004358200. PMID 10915792.
Chen F, Studzinski GP (June 2001). "Expression of the neuronal cyclin-dependent kinase 5 activator p35Nck5a in human monocytic cells is associated with differentiation". Blood. 97 (12): 3763–7. doi:10.1182/blood.V97.12.3763. PMID 11389014.
Tarricone C, Dhavan R, Peng J, Areces LB, Tsai LH, Musacchio A (September 2001). "Structure and regulation of the CDK5-p25(nck5a) complex". Mol. Cell. 8 (3): 657–69. doi:10.1016/S1097-2765(01)00343-4. PMID 11583627.
Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ (March 2002). "The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity". J. Biol. Chem. 277 (9): 7324–32. doi:10.1074/jbc.M107270200. PMID 11741927.

External links

Human CDK5R1 genome location and CDK5R1 gene details page in the UCSC Genome Browser.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000176749 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048895 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8090221-5] Tsai LH, Delalle I, Caviness VS Jr, Chae T, Harlow E (October 1994). "p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5". Nature. 371 (6496): 419–23. doi:10.1038/371419a0. PMID 8090221. S2CID 4267944.

[entrez-6] "Entrez Gene: CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)".

[pmid19067971-7] Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

[pmid12084709-8] Cheng K, Li Z, Fu WY, Wang JH, Fu AK, Ip NY (August 2002). "Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35". J. Biol. Chem. 277 (35): 31988–93. doi:10.1074/jbc.M201161200. PMID 12084709.

[pmid11113134-9] Floyd SR, Porro EB, Slepnev VI, Ochoa GC, Tsai LH, De Camilli P (March 2001). "Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2". J. Biol. Chem. 276 (11): 8104–10. doi:10.1074/jbc.M008932200. PMID 11113134.

[pmid11168528-10] Kesavapany S, Lau KF, McLoughlin DM, Brownlees J, Ackerley S, Leigh PN, Shaw CE, Miller CC (January 2001). "p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interaction". Eur. J. Neurosci. 13 (2): 241–7. doi:10.1046/j.1460-9568.2001.01376.x. PMID 11168528.

[pmid12223541-11] Dhavan R, Greer PL, Morabito MA, Orlando LR, Tsai LH (September 2002). "The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner". J. Neurosci. 22 (18): 7879–91. doi:10.1523/JNEUROSCI.22-18-07879.2002. PMC 6758084. PMID 12223541.

[pmid10915792-12] Wang X, Ching YP, Lam WH, Qi Z, Zhang M, Wang JH (October 2000). "Identification of a common protein association region in the neuronal Cdk5 activator". J. Biol. Chem. 275 (41): 31763–9. doi:10.1074/jbc.M004358200. PMID 10915792.

[pmid11389014-13] Chen F, Studzinski GP (June 2001). "Expression of the neuronal cyclin-dependent kinase 5 activator p35Nck5a in human monocytic cells is associated with differentiation". Blood. 97 (12): 3763–7. doi:10.1182/blood.V97.12.3763. PMID 11389014.

[pmid11583627-14] Tarricone C, Dhavan R, Peng J, Areces LB, Tsai LH, Musacchio A (September 2001). "Structure and regulation of the CDK5-p25(nck5a) complex". Mol. Cell. 8 (3): 657–69. doi:10.1016/S1097-2765(01)00343-4. PMID 11583627.

[pmid11741927-15] Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ (March 2002). "The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity". J. Biol. Chem. 277 (9): 7324–32. doi:10.1074/jbc.M107270200. PMID 11741927.

CDK5R1

Function

Interactions

See also

References

Further reading

External links