Protein SET

Protein SET is a protein that in humans is encoded by the SET gene.[5][6][7]

SET
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSET, 2PP2A, I2PP2A, IGAAD, IPP2A2, PHAPII, TAF-I, TAF-IBETA, SET nuclear proto-oncogene, MRD58
External IDsOMIM: 600960 MGI: 1860267 HomoloGene: 55707 GeneCards: SET
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q34.11Start128,683,424 bp[1]
End128,696,400 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

6418

56086

Ensembl

ENSG00000119335

ENSMUSG00000054766

UniProt

Q01105

Q9EQU5

RefSeq (mRNA)

NM_001122821
NM_001248000
NM_001248001
NM_003011
NM_001374326

NM_001204875
NM_023871

RefSeq (protein)

NP_001116293
NP_001234929
NP_001234930
NP_003002
NP_001361255

NP_001191804
NP_076360

Location (UCSC)Chr 9: 128.68 – 128.7 MbChr 2: 30.06 – 30.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

Protein SET has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000119335 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000054766 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. von Lindern M, van Baal S, Wiegant J, Raap A, Hagemeijer A, Grosveld G (Aug 1992). "Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene". Molecular and Cellular Biology. 12 (8): 3346–55. doi:10.1128/mcb.12.8.3346. PMC 364582. PMID 1630450.
  6. Li M, Makkinje A, Damuni Z (May 1996). "The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A". The Journal of Biological Chemistry. 271 (19): 11059–62. doi:10.1074/jbc.271.19.11059. PMID 8626647.
  7. "Entrez Gene: SET SET translocation (myeloid leukemia-associated)".
  8. Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (Jan 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell. 104 (1): 119–30. doi:10.1016/s0092-8674(01)00196-9. PMID 11163245. S2CID 11144887.
  9. Fan Z, Beresford PJ, Zhang D, Lieberman J (Apr 2002). "HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A". Molecular and Cellular Biology. 22 (8): 2810–20. doi:10.1128/mcb.22.8.2810-2820.2002. PMC 133744. PMID 11909973.
  10. Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ (Mar 2002). "The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity". The Journal of Biological Chemistry. 277 (9): 7324–32. doi:10.1074/jbc.M107270200. PMID 11741927.
  11. Miyamoto S, Suzuki T, Muto S, Aizawa K, Kimura A, Mizuno Y, Nagino T, Imai Y, Adachi N, Horikoshi M, Nagai R (Dec 2003). "Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain". Molecular and Cellular Biology. 23 (23): 8528–41. doi:10.1128/mcb.23.23.8528-8541.2003. PMC 262669. PMID 14612398.
  12. Fan Z, Beresford PJ, Oh DY, Zhang D, Lieberman J (Mar 2003). "Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor". Cell. 112 (5): 659–72. doi:10.1016/s0092-8674(03)00150-8. PMID 12628186. S2CID 14019153.

Further reading

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