CLASP1

Cytoplasmic linker associated protein 1, also known as CLASP1, is a protein which in humans is encoded by the CLASP1 gene.[5]

CLASP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCLASP1, MAST1, cytoplasmic linker associated protein 1
External IDsOMIM: 605852 MGI: 1923957 HomoloGene: 41024 GeneCards: CLASP1
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q14.2-q14.3Start121,337,776 bp[1]
End121,649,587 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

23332

76707

Ensembl

ENSG00000074054

ENSMUSG00000064302

UniProt

Q7Z460

Q80TV8

RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 2: 121.34 – 121.65 MbChr 1: 118.39 – 118.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

CLASP1 belongs to a family of microtubule-associated proteins involved in attachment of microtubules to the cell cortex in animals[6] and plants.[7] CLASPs, such as CLASP1, interact with CLIPs (e.g., CLIP1). In animal cells, CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle.[5][8] CLASP1 controls the interactions of astral microtubules with the cell cortex in mitosis, which is important for the proper positioning and orientation of the spindle.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000074054 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000064302 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: CLASP1 cytoplasmic linker associated protein 1".
  6. Lansbergen G, Grigoriev I, Mimori-Kiyosue Y, et al. (2006). "CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta". Developmental Cell. 11 (1): 21–32. doi:10.1016/j.devcel.2006.05.012. PMID 16824950.
  7. Ambrose JC, Wasteneys GO (2008). "CLASP Modulates Microtubule-Cortex Interaction during Self-Organization of Acentrosomal Microtubules". Molecular Biology of the Cell. 19 (11): 4730–4737. doi:10.1091/mbc.E08-06-0665. PMC 2575154. PMID 18716054.
  8. Maiato H, Fairley EA, Rieder CL, Swedlow JR, Sunkel CE, Earnshaw WC (June 2003). "Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics". Cell. 113 (7): 891–904. doi:10.1016/S0092-8674(03)00465-3. PMID 12837247.
  9. Samora, Catarina P.; Mogessie, Binyam; Conway, Leslie; Ross, Jennifer L.; Straube, Anne; McAinsh, Andrew D. (7 August 2011). "MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis". Nature Cell Biology. 13 (9): 1040–1050. doi:10.1038/ncb2297. PMID 21822276. S2CID 8869880.

Further reading


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