CSNK1E

CSNK1E
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4HNI, 4HOK
Identifiers
Aliases	CSNK1E, CKIepsilon, HCKIE, Casein kinase 1 isoform epsilon, casein kinase 1 epsilon, CKIe
External IDs	OMIM: 600863 MGI: 1351660 HomoloGene: 121695 GeneCards: CSNK1E
Gene location (Human)
Chr.	Chromosome 22 (human)[1]
End	38,318,084 bp[1]
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)[2]
End	79,455,566 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• transferase activity; • protein kinase activity; • nucleotide binding; • kinase activity; • protein serine/threonine kinase activity; • GO:0001948 protein binding; • ATP binding; • RNA binding;
Cellular component	• cytoplasm; • cytosol; • cell nucleus; • nucleoplasm; • growth cone; • neuron projection; • neuronal cell body;
Biological process	• phosphorylation; • rhythmic process; • Wnt signaling pathway; • negative regulation of protein binding; • protein phosphorylation; • G2/M transition of mitotic cell cycle; • peptidyl-serine phosphorylation; • DNA repair; • signal transduction; • endocytosis; • regulation of cell shape; • rRNA processing; • ciliary basal body docking; • positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation; • positive regulation of proteasomal ubiquitin-dependent protein catabolic process; • circadian regulation of gene expression; • regulation of circadian rhythm; • regulation of cellular protein localization; • positive regulation of non-canonical Wnt signaling pathway; • regulation of G2/M transition of mitotic cell cycle; • circadian behavior; • positive regulation of amyloid-beta formation; • cellular response to nerve growth factor stimulus; • peptidyl-threonine phosphorylation; • canonical Wnt signaling pathway; • positive regulation of canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	1454
	27373
	ENSG00000213923
	ENSMUSG00000022433
	P49674
	Q9JMK2
	NM_001894; NM_152221
	NM_013767; NM_001289898; NM_001289899; NM_001359862; NM_001359863
	NP_001885; NP_689407
	NP_001276827; NP_001276828; NP_038795; NP_001346791; NP_001346792
	Wikidata
View/Edit Human	View/Edit Mouse

Casein kinase I isoform epsilon is an enzyme that in humans is encoded by the CSNK1E gene.[5][6]

Function

The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate proteins of the Period family of circadian rhythm proteins. A homolog of this mammalian protein can be found in Drosophila melanogaster. Known as doubletime, this protein also plays a role in the phosphorylation of proteins involved in circadian rhythms. Two transcript variants encoding the same protein have been found for this gene.[7]

Interactions

CSNK1E has been shown to interact with PER1[8] and AXIN1.[9]

Inhibitors

Selective

PF-4800567

Non-selective

PF-670462 (also inhibits CK1-δ)

References

GRCh38: Ensembl release 89: ENSG00000213923 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022433 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Fish KJ, Cegielska A, Getman ME, Landes GM, Virshup DM (Jun 1995). "Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family". The Journal of Biological Chemistry. 270 (25): 14875–83. doi:10.1074/jbc.270.25.14875. PMID 7797465.
Sakanaka C, Leong P, Xu L, Harrison SD, Williams LT (Oct 1999). "Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function". Proceedings of the National Academy of Sciences of the United States of America. 96 (22): 12548–52. doi:10.1073/pnas.96.22.12548. PMC 22983. PMID 10535959.
"Entrez Gene: CSNK1E casein kinase 1, epsilon".
Vielhaber E, Eide E, Rivers A, Gao ZH, Virshup DM (Jul 2000). "Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon". Molecular and Cellular Biology. 20 (13): 4888–99. doi:10.1128/MCB.20.13.4888-4899.2000. PMC 85940. PMID 10848614.
Zhang Y, Qiu WJ, Chan SC, Han J, He X, Lin SC (May 2002). "Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways". The Journal of Biological Chemistry. 277 (20): 17706–12. doi:10.1074/jbc.M111982200. PMID 11884395.

External links

Human CSNK1E genome location and CSNK1E gene details page in the UCSC Genome Browser.
PDBe-KB provides an overview of all the structure information available in the PDB for Human Casein kinase I isoform epsilon (CSNK1E)

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000213923 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022433 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7797465-5] Fish KJ, Cegielska A, Getman ME, Landes GM, Virshup DM (Jun 1995). "Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family". The Journal of Biological Chemistry. 270 (25): 14875–83. doi:10.1074/jbc.270.25.14875. PMID 7797465.

[pmid10535959-6] Sakanaka C, Leong P, Xu L, Harrison SD, Williams LT (Oct 1999). "Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function". Proceedings of the National Academy of Sciences of the United States of America. 96 (22): 12548–52. doi:10.1073/pnas.96.22.12548. PMC 22983. PMID 10535959.

[7] "Entrez Gene: CSNK1E casein kinase 1, epsilon".

[pmid10848614-8] Vielhaber E, Eide E, Rivers A, Gao ZH, Virshup DM (Jul 2000). "Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon". Molecular and Cellular Biology. 20 (13): 4888–99. doi:10.1128/MCB.20.13.4888-4899.2000. PMC 85940. PMID 10848614.

[pmid11884395-9] Zhang Y, Qiu WJ, Chan SC, Han J, He X, Lin SC (May 2002). "Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways". The Journal of Biological Chemistry. 277 (20): 17706–12. doi:10.1074/jbc.M111982200. PMID 11884395.