Chitin disaccharide deacetylase

Chitin disaccharide deacetylase (EC 3.5.1.105, chitobiose amidohydolase, COD, chitin oligosaccharide deacetylase, chitin oligosaccharide amidohydolase) is an enzyme with systematic name 2-(acetylamino)-4-O-(2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucopyranose acetylhydrolase.[1][2][3][4] This enzyme catalyses the following chemical reaction

2-(acetylamino)-4-O-[2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl]-2-deoxy-beta-D-glucopyranose + H2O 2-(acetylamino)-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-beta-D-glucopyranose + acetate
Chitin disaccharide deacetylase
Identifiers
EC number3.5.1.105
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Chitin oligosaccharide deacetylase is present in Vibrio strains.

References
  1. Kadokura K, Rokutani A, Yamamoto M, Ikegami T, Sugita H, Itoi S, Hakamata W, Oku T, Nishio T (May 2007). "Purification and characterization of Vibrio parahaemolyticus extracellular chitinase and chitin oligosaccharide deacetylase involved in the production of heterodisaccharide from chitin". Applied Microbiology and Biotechnology. 75 (2): 357–65. doi:10.1007/s00253-006-0831-6. PMID 17334758.
  2. Hirano T, Kadokura K, Ikegami T, Shigeta Y, Kumaki Y, Hakamata W, Oku T, Nishio T (September 2009). "Heterodisaccharide 4-O-(N-acetyl-beta-D-glucosaminyl)-D-glucosamine is a specific inducer of chitinolytic enzyme production in Vibrios harboring chitin oligosaccharide deacetylase genes". Glycobiology. 19 (9): 1046–53. doi:10.1093/glycob/cwp088. PMID 19553519.
  3. Ohishi K, Yamagishi M, Ohta T, Motosugi M, Izumida H, Sano H, Adachi K, Miwa T (1997). "Purification and properties of two deacetylases produced by Vibrio alginolyticus H-8". Biosci. Biotechnol. Biochem. 61: 1113–1117. doi:10.1271/bbb.61.1113.
  4. Ohishi K, Murase K, Ohta T, Etoh H (2000). "Cloning and sequencing of the deacetylase gene from Vibrio alginolyticus H-8". Journal of Bioscience and Bioengineering. 90 (5): 561–3. doi:10.1263/jbb.90.561. PMID 16232910.
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