Coiled-coil domain containing protein 120

The mRNA transcript of CCDC120 contains a 120bp repeat near the 3' end.[8]

120bp repeat is visible on the graph.

CCDC120 has 3 identifiable paralogs in humans, FERM Domain Containing 4A, FERM domain Containing 4B, and C1orf106.[9]

The orthologous space of CCDC120 can be traced back as far as fish such as Danio rerio, Oryzias latipes, and Dicentrarchus labrax.[9]

Usher Syndrome 1C Binding Protein 1, CYTH2, MDFI, Centrosomal Protein 170kDa Pseudogene 1, and Keratin 15 have all been shown experimentally to interact with CCDC120 [12] Other interactions have been identified by coexpression and datamining and can be seen in the figure.

Shows the protein interactions for CCDC120 with experimental evidence indicated by a pink line, coexpression by dark green lines, and textmining by light green lines. This image was generated using the STRING 9.05 application. (http://string-db.org/)

Algorithms suggest a number of sites of Serine phosphorylation as well as a few sites of Threonine and Tyrosine phosphorylation. Many of these sites are conserved in Gorilla gorilla gorilla, Mus musculus, and Danio rerio. There is one potential N-Glycosylation site identified.[13]

The protein structure of CCDC120 is predicted to contain, as the name implies, a 65 amino acid coiled coil from positions 109-173.[14] Multiple algorithms identify 3 distinct sites where alpha-helical structures could form which are conserved in Gorilla gorilla gorilla and Danio rerio. Algorithms do not agree on any location for a beta sheet structure.[15]

Algorithms suggest that CCDC120 has a promoter of 601bp,[16] this promoter contains a number of possible transcription factor sites as shown in the figure.

The nucleotide sequence of the 601 bp promoter for CCDC120 is shown with key transcription factors that are well-identified by algorithms labeled. (http://www.genomatix.de/)