Cue reactivity

A meta-analysis of 41 cue reactivity studies with people that have an alcohol, heroin, or cocaine addiction strongly supports the finding that people who have addictions have significant cue-specific reactions to drug-related stimuli.[1] In general, these individuals, regardless of drug of abuse, report robust increases in craving and exhibit modest changes in autonomic responses, such as increases in heart rate and skin conductance and decreases in skin temperature, when exposed to drug-related versus neutral stimuli. Surprisingly, despite their obvious clinical relevance, drug use or drug-seeking behaviors are seldom measured in cue reactivity studies. However, when drug-use measures are used in cue reactivity studies the typical finding is a modest increase in drug-seeking or drug-use behavior.

Since people with substance use disorders are highly reactive to environmental cues previously associated with drug use, a common treatment strategy is to advise them to avoid people and situations formerly associated with drug use. For example, a person attempting to quit smoking should avoid other people who smoke and places where smoking is prevalent (like bars in places where smoking is allowed in bars). Although the relationship between cue reactivity in the laboratory and relapse to drug use in the real world is still poorly understood, considerable anecdotal evidence from drug treatment programs and smoking cessation counselors suggests that people with substance use disorders who seek treatment are more successful at remaining abstinent if they take special care to avoid cues associated with prior drug use.

• Conditioned place preference
• Nucleus Accumbens – Addiction
• Motivational salience – Addiction