Cyclohexane-1,2-diol dehydrogenase
In enzymology, a cyclohexane-1,2-diol dehydrogenase (EC 1.1.1.174) is an enzyme that catalyzes the chemical reaction
- trans-cyclohexane-1,2-diol + NAD+ 2-hydroxycyclohexan-1-one + NADH + H+
| cyclohexane-1,2-diol dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.174 | ||||||||
| CAS number | 62628-27-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are trans-cyclohexane-1,2-diol and NAD+, whereas its 3 products are 2-hydroxycyclohexan-1-one, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is trans-cyclohexane-1,2-diol:NAD+ 1-oxidoreductase. This enzyme participates in caprolactam degradation.
References
- Davey JF, Trudgill PW (1977). "The metabolism of trans-cyclohexan-1,2-diol by an Acinetobacter species". Eur. J. Biochem. 74 (1): 115–27. doi:10.1111/j.1432-1033.1977.tb11373.x. PMID 856571.
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