DSE (gene)

Dermatan-sulfate epimerase is an enzyme that in humans is encoded by the DSE gene.[5][6][7][8][9]

DSE
Identifiers
AliasesDSE, DSEP, DSEPI, EDSMC2, SART-2, SART2, DS-epi1, dermatan sulfate epimerase
External IDsOMIM: 605942 MGI: 2443455 HomoloGene: 8354 GeneCards: DSE
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6q22.1Start116,254,173 bp[1]
End116,444,861 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

29940

212898

Ensembl

ENSG00000111817

ENSMUSG00000039497

UniProt

Q9UL01

Q8BLI4

RefSeq (mRNA)

NM_172508

RefSeq (protein)

NP_766096

Location (UCSC)Chr 6: 116.25 – 116.44 MbChr 10: 34.15 – 34.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is an epimerase required for biosynthesis of dermatan sulfate[10] and a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is localized to the endoplasmic reticulum. Two transcript variants encoding the same protein have been found for this gene.[7]

Clinical significance

References

  1. GRCh38: Ensembl release 89: ENSG00000111817 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000039497 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Sasatomi T, Suefuji Y, Matsunaga K, Yamana H, Miyagi Y, Araki Y, Ogata Y, Itoh K, Shirouzu K (Mar 2002). "Expression of tumor rejection antigens in colorectal carcinomas". Cancer. 94 (6): 1636–41. doi:10.1002/cncr.10421. PMID 11920522. S2CID 33045822.
  6. Maccarana M, Olander B, Malmstrom J, Tiedemann K, Aebersold R, Lindahl U, Li JP, Malmstrom A (Apr 2006). "Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2". J Biol Chem. 281 (17): 11560–8. doi:10.1074/jbc.M513373200. PMID 16505484.
  7. "Entrez Gene: DSE dermatan sulfate epimerase".
  8. Sasatomi T, Suefuji Y, Matsunaga K, Yamana H, Miyagi Y, Araki Y, Ogata Y, Itoh K, Shirouzu K (March 2002). "Expression of tumor rejection antigens in colorectal carcinomas". Cancer. 94 (6): 1636–41. doi:10.1002/cncr.10421. PMID 11920522. S2CID 33045822.
  9. Maccarana M, Olander B, Malmström J, Tiedemann K, Aebersold R, Lindahl U, Li JP, Malmström A (April 2006). "Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2". J. Biol. Chem. 281 (17): 11560–8. doi:10.1074/jbc.M513373200. PMID 16505484.
  10. Malstrom, Anders (1982). "Biosynthesis of dermatan sulphate: Assay and properties of the uronosyl C-5 epimerase". Biochem. J. 201 (3): 489–93. doi:10.1042/bj2010489. PMC 1163673. PMID 7092807. Retrieved 14 August 2020.

Further reading


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