Dale Sanders

Professor Dale Sanders, FRS (born 13 May 1953) is a director of the John Innes Centre,[2] an internationally leading institute for research in plant sciences and microbiology in Norwich, England.

Not to be confused with Dale Sanders (railroad photographer).

Dale Sanders
Born (1953-05-13) 13 May 1953[1]
Alma mater
AwardsFRS (2001)
Scientific career
Institutions
ThesisThe regulation of ion transport in characean cells (1978)
Website

Education

Sanders was educated at The Hemel Hempstead School. He gained a Bachelor of Arts degree from the University of York reading Biology from 1971 – 1974, graduating with 1st Class Honours.[1]

He did his PhD alongside Professor Enid AC MacRobbie FRS at Darwin College, Cambridge in 1978 in Department of Plant Sciences. In 1993 Sanders earned his Sc.D. from the University of Cambridge.

Research

Sanders’ research explores the transport of ions across plant cell membranes[3] and the roles of ions in signalling and nutrient status.

Sanders’ first significant finding during his PhD was to provide unequivocal evidence that inorganic anion uptake in plants is powered by a proton gradient.[4][5]

In subsequent research as a post-doc at Yale University School of Medicine he pioneered methods to measure and interpret the interplay between control of intracellular pH and activity of the plasma membrane proton pump. This work on a fungus served as a paradigm for understanding the interplay of membrane transport and cellular homeostasis in fungal and plant cell.

On taking an academic position at the University of York, Sanders developed novel electrophysiological approaches to plant cellular signalling and membrane transport. The Sanders lab demonstrated a key link between changes in cytosolic free calcium and photosynthetic activity, and through many technical developments showed how membrane transport at the plant vacuole is energised and regulated in response to physiological demand.  

Among other discoveries, Sanders has identified membrane transporters which transport zinc across plant membranes,[6] establishing principles for biofortification of cereal crops with essential human mineral nutrients.[7] He also molecularly characterised calcium permeable channels[8][9] and is interested in how calcium fluxes are initiated and respond to plant stress such as attack by aphids.[10]

Sander’s current research focuses on how plant cells respond to changes in their environment[11] and how they store the nutrients they acquire.[7] In particular, his group work on how transport of chemical elements across cell membranes in plants is integrated with cellular signalling and nutritional status.[12]

Career

Sander’s research career began at the Yale University School of Medicine, first as a Postdoctoral Research Fellow (1978–79) and then as a Postdoctoral Research Associate (1979–83).

After a stint as a Visiting Research Fellow in the University of Biological Sciences at the University of Sydney (1983), Sanders moved into the Biology Department at the University of York in 1983, first as a lecturer (1983–89), a Reader (1989-1992), a Professor (1992-2010), also acting as the Head of Department (2004-2010).[13]

In 2010 Sanders moved to the John Innes Centre, Norwich as Director and Group Leader,[14] establishing new collaborations with the Chinese Academy of Sciences.[15]

Awards and honours

Sanders was elected a Fellow of the Royal Society in 2001.[16]

Throughout his career Sanders has received a number of additional awards and honours, including;

  • Fellowships: Inaugural Fellow of the Royal Society of Biology (2009)
  • Elected to Royal Society Council 2004 – 2006)
  • Royal Society/Leverhulme Trust Senior Research Fellowship (1997-1998)
  • Nuffield Foundation Science Research Fellowship (1989-1990)
  • James Hudson Brown Fellowship, Yale University (1979-1980)
  • Prizes: Koerber Foundation European Science Prize (2001)
  • President's Medal, Society for Experimental Biology (1987)
  • Honorary Chairs: University of York (2010–present)
  • University of East Anglia (2010–present)
  • Agricultural Genomics Institute Shenzhen (2018–present)

References
  1. "SANDERS, Prof. Dale". Who's Who 2014, A & C Black, an imprint of Bloomsbury Publishing plc, 2014; online edn, Oxford University Press.(subscription required)
  2. "Dale Sanders announced as new director for John Innes Centre". Archived from the original on 31 December 2010.
  3. Dodd, Antony N.; Kudla, Jörg; Sanders, Dale (2010). "The language of calcium signaling". Annual Review of Plant Biology. 61: 593–620. doi:10.1146/annurev-arplant-070109-104628. ISSN 1545-2123. PMID 20192754.
  4. Allen, G. J.; Sanders, D. (September 1995). "Calcineurin, a Type 2B Protein Phosphatase, Modulates the Ca2+-Permeable Slow Vacuolar Ion Channel of Stomatal Guard Cells". The Plant Cell. 7 (9): 1473–1483. doi:10.1105/tpc.7.9.1473. ISSN 1532-298X. PMID 12242407.
  5. Davies, J M; Poole, R J; Rea, P A; Sanders, D (15 December 1992). "Potassium transport into plant vacuoles energized directly by a proton-pumping inorganic pyrophosphatase". Proceedings of the National Academy of Sciences of the United States of America. 89 (24): 11701–11705. ISSN 0027-8424. PMID 1334545.
  6. Blaudez, Damien; Kohler, Annegret; Martin, Francis; Sanders, Dale; Chalot, Michel (1 December 2003). "Poplar Metal Tolerance Protein 1 Confers Zinc Tolerance and Is an Oligomeric Vacuolar Zinc Transporter with an Essential Leucine Zipper Motif". The Plant Cell. 15 (12): 2911–2928. doi:10.1105/tpc.017541. ISSN 1040-4651. PMID 14630973.
  7. Palmgren, Michael G.; Clemens, Stephan; Williams, Lorraine E.; Krämer, Ute; Borg, Søren; Schjørring, Jan K.; Sanders, Dale (1 September 2008). "Zinc biofortification of cereals: problems and solutions". Trends in Plant Science. 13 (9): 464–473. doi:10.1016/j.tplants.2008.06.005. ISSN 1360-1385.
  8. Allen, G. J.; Sanders, D. (1 May 1994). "Two Voltage-Gated, Calcium Release Channels Coreside in the Vacuolar Membrane of Broad Bean Guard Cells". The Plant Cell. 6 (5): 685–694. doi:10.1105/tpc.6.5.685. ISSN 1040-4651. PMID 12244254.
  9. Allen, G. J.; Muir; Sanders, D. (5 May 1995). "Release of Ca2+ from individual plant vacuoles by both InsP3 and cyclic ADP-ribose". Science. 268 (5211): 735–737. doi:10.1126/science.7732384. ISSN 0036-8075. PMID 7732384.
  10. Vincent, Thomas R.; Avramova, Marieta; Canham, James; Higgins, Peter; Bilkey, Natasha; Mugford, Sam T.; Pitino, Marco; Toyota, Masatsugu; Gilroy, Simon; Miller, Anthony J.; Hogenhout, Saskia A. (1 June 2017). "Interplay of Plasma Membrane and Vacuolar Ion Channels, Together with BAK1, Elicits Rapid Cytosolic Calcium Elevations in Arabidopsis during Aphid Feeding". The Plant Cell. 29 (6): 1460–1479. doi:10.1105/tpc.17.00136. ISSN 1040-4651. PMID 28559475.
  11. Sanders, Dale (2020). "The salinity challenge". New Phytologist. 225 (3): 1047–1048. doi:10.1111/nph.16357. ISSN 1469-8137. PMC 6973154. PMID 31894589.
  12. Menguer, Paloma K.; Vincent, Thomas; Miller, Anthony J.; Brown, James K. M.; Vincze, Eva; Borg, Søren; Holm, Preben Bach; Sanders, Dale; Podar, Dorina (January 2018). "Improving zinc accumulation in cereal endosperm using HvMTP1, a transition metal transporter". Plant Biotechnology Journal. 16 (1): 63–71. doi:10.1111/pbi.12749. ISSN 1467-7652. PMC 5785336. PMID 28436146.
  13. "Dale Sanders Laboratory". www.york.ac.uk. Retrieved 20 July 2020.
  14. "Professor Dale Sanders". John Innes Centre. 30 November 2018. Retrieved 20 July 2020.
  15. JIC and Chinese Academy of Sciences collaborate on new Centre of Excellence Archived 19 January 2015 at the Wayback Machine
  16. "Dale Sanders | Royal Society". royalsociety.org. Retrieved 20 July 2020.
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