David Eisenberg

David S. Eisenberg (born 15 March 1939) is an American biochemist and biophysicist best known for his contributions to structural biology and computational molecular biology, a professor at the University of California, Los Angeles since the early 1970s and director of the UCLA-DOE Institute for Genomics & Proteomics since the early 1990s, as well as a member of the California NanoSystems Institute (CNSI) at UCLA.[8][9][10][11][12][13][14]

For the American physician, see David M. Eisenberg.
David Eisenberg
David Eisenberg
Born (1939-03-15) March 15, 1939
Chicago, United States
Alma materHarvard University (undergraduate)
The Queen's College, Oxford (postgraduate)
AwardsHarvey Prize (2008)
ISCB Senior Scientist Award (2013)[1]
Scientific career
FieldsProteins[2]
Amyloid[3]
Structural biology[4][5][6]
InstitutionsHoward Hughes Medical Institute
University of Oxford
University of California, Los Angeles
Harvard University
California Institute of Technology
Princeton University
ThesisSome problems in the electronic structure of molecules (1965)
Doctoral advisorCharles Coulson
Doctoral studentsMichael Gribskov
Other notable studentsCharlotte Deane[7]
Website

Education

Eisenberg attended Harvard University and graduated in 1961 with an A.B. in Biochemical Sciences. He went on to the University of Oxford, where he was awarded a D.Phil in 1965[15] for research supervised by Charles Coulson.

Research

Eisenberg's current research focuses on the structural biology of amyloidogenic proteins, while his computational efforts largely center on the development of bioinformatic/proteomic methodologies for elucidation and analysis of protein interaction networks. His research group hosts the Database of Interacting Proteins.[16]

Career
  • Postdoctoral research, Princeton University (1964–1966; with Walter Kauzmann)
  • Postdoctoral research, California Institute of Technology (1966–1969; with Richard E. Dickerson)
  • Professor, Department of Chemistry & Biochemistry, UCLA, USA (1969–Present)
  • Professor, Department of Biological Chemistry, UCLA Medical School
  • Director, UCLA-DOE Institute for Genomics & Proteomics (1993–Present)
  • Member, California NanoSystems Institute (CNSI), UCLA
  • Investigator, Howard Hughes Medical Institute (2001–Present)

Awards

He was the recipient of Harvey Prize (Human Health) 2008 in recognition of his contributions in unfolding the structure of amyloid fibrils. The award was presented to him at a ceremony that took place on March 23, 2009 at the Technion. This recently recognized protein state provides opportunities to understand cells in health and disease.[17]

References
  1. Fogg, C. N.; Kovats, D. E. (2013). "International Society for Computational Biology Honors David Eisenberg with 2013 Accomplishment by a Senior Scientist Award". PLoS Computational Biology. 9 (6): e1003116. doi:10.1371/journal.pcbi.1003116. PMC 3681620.
  2. Eisenberg, D.; McLachlan, A. D. (1986). "Solvation energy in protein folding and binding". Nature. 319 (6050): 199–203. doi:10.1038/319199a0. PMID 3945310.
  3. Balbirnie, M.; Grothe, R.; Eisenberg, D. S. (2001). "An amyloid-forming peptide from the yeast prion Sup35 reveals a dehydrated beta -sheet structure for amyloid". Proceedings of the National Academy of Sciences. 98 (5): 2375–2380. doi:10.1073/pnas.041617698. PMC 30146. PMID 11226247.
  4. Lüthy, R.; Bowie, J. U.; Eisenberg, D. (1992). "Assessment of protein models with three-dimensional profiles". Nature. 356 (6364): 83–85. doi:10.1038/356083a0. PMID 1538787.
  5. Chapman, M. S.; Suh, S. W.; Curmi, P. M.; Cascio, D.; Smith, W. W.; Eisenberg, D. S. (1988). "Tertiary structure of plant RuBisCO: Domains and their contacts". Science. 241 (4861): 71–74. doi:10.1126/science.3133767. PMID 3133767.
  6. David Eisenberg publications indexed by Google Scholar
  7. http://eisenberglab.mbi.ucla.edu/?page_id=87
  8. HHMI profile of David Eisenberg
  9. The Eisenberg research lab at UCLA
  10. UCLA-DOE Institute for Genomics & Proteomics
  11. David Eisenberg’s speech during the Harvey Prize ceremony on YouTube
  12. Eisenberg, David; Kauzmann, Walter (2005). The structure and properties of water. Oxford: Clarendon Press. ISBN 0-19-857026-0.
  13. List of publications from Microsoft Academic
  14. David Eisenberg's publications indexed by the Scopus bibliographic database. (subscription required)
  15. Eisenberg, David J. (1965). Some problems in the electronic structure of molecules (PhD thesis). University of Oxford.
  16. Salwinski, L.; Miller, C. S.; Smith, A. J.; Pettit, F. K.; Bowie, J. U.; Eisenberg, D. (2004). "The Database of Interacting Proteins: 2004 update". Nucleic Acids Research. 32 (90001): D449–D451. doi:10.1093/nar/gkh086. PMC 308820. PMID 14681454.
  17. Harvey Prize Award
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