Desmond's

The Ambroses are the central family around which the show was built.

• Desmond Ambrose (Norman Beaton) was the main character and owner of the barbershop named after him. His friends and family occasionally make reference to his poor barbering skills. Desmond constantly talked about retiring and returning home to Guyana for good, although Shirley was reluctant to go with him. In the spin-off Porkpie, it was revealed that Desmond had died (as Norman Beaton had died the previous year).
• Shirley Ambrose (Carmen Munroe), Desmond's wife and mother of their three children, often solved the problems of the other characters. Shirley was the only member of the Ambrose family not to appear in an episode of the spin-off Porkpie as it was revealed that she had gone back to live in Guyana, in the series.
• Michael Ambrose (Geff Francis), Desmond and Shirley's elder son, was an assistant bank manager, who later became a manager. Unlike the rest of the Ambrose family, he was not introduced until the second episode, when Shirley suggested that Desmond go to the bank and get a loan to renovate the shop.
• Gloria Ambrose (Kimberly Walker) was the only daughter of Desmond and Shirley. She had dreams of becoming a fashion writer.
• Sean Ambrose (Justin Pickett) was the youngest child, who frequently rapped and was experienced in computer use. He later went to university.

• Augustus Neapolitan Cleveland "Porkpie" Grant (Ram John Holder) was a childhood friend of Desmond's. His nickname derived from his habit of always wearing a pork pie hat, even as a young man back in Guyana. His wife Gwendolyn had left him many years earlier after catching him in bed with her best friend Hyacinth Green, who appeared in the final series. Porkpie's wife went to live in Canada, taking their two young daughters with her. Although he had two daughters he often talked about his daughter Denise, who appeared in the fifth episode of the third series, while there was no mention of his other daughter. Porkpie later had his own spin-off series, Porkpie.
• Matthew (Gyearbuor Asante) was an eternal student from The Gambia. He would often quote "old African sayings" and usually followed up by asking the listener to "think about it".
• Tony (Dominic Keating) was Desmond's first assistant barber and the third white character to appear in the series. In the final series, it is mentioned Tony had left to cut hair overseas.
• Ricky Flaxman (Dean Gatiss) was Tony's replacement in the final series. Desmond gave him the job as the new barber's assistant because he knew his father and promised him a favour for supplying an alibi. He moved into Gloria's room after she moved out to live with Alex. He is often referred to as "Small Boy" by Matthew.
• Lee "The Peckham Prince" Stanley (Robbie Gee) was the local wide-boy wheeler-dealer, often trying to sell his wares to the regulars in the shop. He was like a son to Desmond and Shirley as they looked after him while he was in care and they knew his mother. Lee's mother revealed the identity of his father in the fourth episode of the fourth series. She visited the barber shop to find Lee on the day he went to Liverpool to find her. On Lee's return to Peckham, he was reunited with his mother after 28 years.
• Louise Dixon (Lisa Geoghan) was Gloria's best friend in the first four series, and also the first white character to appear in the series. She went away to university between the fourth and fifth series.
• Amanda "Mandy" Mosgrove (Matilda Thorpe) was Michael's PA. In episode two of the sixth series, Michael proposed to her and she accepted. She was due to marry Michael towards the end of the series. There was no episode of them getting married as the series had finished during the planning stages of the wedding. In the spin-off series, Porkpie it was revealed that Mandy had married Michael, her surname having become Ambrose.
• Beverley Mcintosh (Joan Ann Maynard) was a good friend of Shirley's and Michael's godmother. She was the local gossip, providing a prudish, old-fashioned viewpoint. She often spoke about her ailments and the medication she had to take, as well as having to prepare her husband's Cuthbert's red mullet (which he later revealed in his only appearance, that he did not like). She always wore a hat that resembled a tea cosy.
• Aunt "Susu" Doreen (Mona Hammond), Shirley's ignorant sister, Porkpie's dream girl and later fiancée. She preferred to be called "Susu" rather than her birth name, but the family, in particular Shirley, would call her Doreen whenever angry with her. In the fourth series, Susu was deported back to Jamaica; however, she was still engaged to Porkpie. In the final series of the spin-off show Porkpie, Susu had turned up out of the blue from Jamaica, after finding out about Porkpie's Lottery win in the West Indian Times newspaper. She claimed to have married an Englishman back in the Caribbean so that she could get a passport to go to England to marry Porkpie. Porkpie later found out that she had run away with all her current husband's savings, sold his electric wheelchair and stolen his passport so that he could not pursue her, and that she only came to England to marry him and claim half of his fortune.
• Vince (Count Prince Miller) was another assistant in the shop in the final series. He was also the drummer in the Georgetown Dreamers.
• Burt (Sol Raye) was a member of The Georgetown Dreamers, a band that Desmond, Porkpie and Vince played in.
• Andrew "Spider" Webb (Robert McKewley) was Sean's best friend and had an open crush on Gloria. He was into ragga music and was an entrepreneur. Although he was Sean's best friend, Sean's family members seemed to disapprove of him and sometimes thought he was a bad influence.
• Bernie (Rhashan Stone) was the first friend that Sean made at university on his first day. He was openly gay.
• Ronni (Teohna Williams) was Gloria's best friend in series 5 and 6.
• Alex Reynolds (Chris Tummings) was Gloria's boyfriend from series 4, a strict vegetarian and an artist. Gloria and Alex moved in together towards the end of the series. It is revealed in the first episode of the Porkpie spin-off series that Alex and Gloria were still together.
• Neville "Nev" James (Treva Etienne) was a family friend who was a Police Constable, later becoming a Detective Constable CID. He also went to school with Lee and Michael as a child. He only appeared in three episodes between the second and third series.
• Lewis (Lewis St. Juste) was very often in the background, using the pay-phone in the barber shop. He has a line or two in a few episodes. He first spoke in the third episode of the second series, when Shirley asked him his name. He used the phone so often that Lee once referred to him as E.T.
• Sweetsticks is sometimes mentioned in the show although he never appears on screen. He dies during the first series, and episode 6 (entitled "Sad News") culminates with the other characters attending his funeral. He was a member of the Georgetown Dreamers, their steel pan player and is often cited by Desmond and Porkpie as having been a ladies' man. Although Sweetsticks never appeared in the show, the repercussions of his actions sometimes form important plot elements, affecting Desmond in the present day. He was revealed to be Lee's father.

Channel 4 DVD has released the first two series on DVD in the UK. Series One was released on 1 October 2007. Series Two was released on 14 April 2008.[7]

Visual Entertainment has begun releasing Desmond's on DVD in Canada. To date they have released the first four series of the show on DVD. Series 1 and 2 were released on 27 March 2007.[8] Series 3 was released on 3 November 2009.[9] On 2 March 2010, VEI released Desmond's- The Collection: Series One to Four, a seven-disc set featuring all episodes from the first four seasons.[10]

All six seasons are available to stream in the UK on the Channel 4 service All 4 and through the streaming services Amazon Prime and Netflix.