Diamine N-acetyltransferase

In enzymology, a diamine N-acetyltransferase (EC 2.3.1.57) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + an alkane-alpha,omega-diamine CoA + an N-acetyldiamine
diamine N-acetyltransferase
Spermidine N-acetyltransferase dodekamer, Vibrio cholerae
Identifiers
EC number2.3.1.57
CAS number54596-36-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are acetyl-CoA and alkane-alpha,omega-diamine, whereas its two products are CoA and N-acetyldiamine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase. Other names in common use include spermidine acetyltransferase, putrescine acetyltransferase, putrescine (diamine)-acetylating enzyme, diamine acetyltransferase, spermidine/spermine N1-acetyltransferase, spermidine N1-acetyltransferase, acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase, putrescine acetylase, and putrescine N-acetyltransferase. This enzyme participates in urea cycle and metabolism of amino groups.

Structural studies

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 2B3U, 2B3V, 2B4B, 2B4D, 2B58, 2B5G, 2BEI, 2F5I, 2FXF, 2G3T, 2JEV, and 2Q4V.

References

    • Ragione FD, Pegg AE (1982). "Purification and characterization of spermidine/spermine N1-acetyltransferase from rat liver". Biochemistry. 21 (24): 6152–8. doi:10.1021/bi00267a020. PMID 7150547.


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