Diiodophenylpyruvate reductase
In enzymology, a diiodophenylpyruvate reductase (EC 1.1.1.96) is an enzyme that catalyzes the chemical reaction
- 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD+ 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + NADH + H+
| diiodophenylpyruvate reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.96 | ||||||||
| CAS number | 37250-31-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 3-(3,5-diiodo-4-hydroxyphenyl)lactate and NAD+, whereas its 3 products are 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-(3,5-diiodo-4-hydroxyphenyl)lactate:NAD+ oxidoreductase. Other names in common use include aromatic alpha-keto acid, KAR, and 2-oxo acid reductase.
References
- Zannoni VG, Weber WW (1966). "Isolation and properties of aromatic alpha-keto acid reductase". J. Biol. Chem. 241 (6): 1340–4. PMID 5935348.
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