Dynamical genetics

Dynamical genetics concerns the study and the interpretation of those phenomena in which physiological enzymatic protein complexes alter the DNA, in a more or less sophisticated way.

The study of such mechanisms is important firstly since they promote useful functions, as for example the immune system recombination (on individual scale) and the crossing-over (on evolutionary scale); secondly since they may sometimes become harmful because of some malfunctioning, causing for example neurodegenerative disorders.

Typical examples of dynamical genetics subjects are:

References

  1. Richards RI, Sutherland GR (1997). "Dynamic mutation: possible mechanisms and significance in human disease". Trends Biochem. Sci. 22 (11): 432–6. doi:10.1016/S0968-0004(97)01108-0. PMID 9397685.
  2. Fonzo, VD; Bersani, E; Aluffi-Pentini, F; Parisi, V (July 2001). "DNA quadruplexes and dynamical genetics". Medical Hypotheses. 57 (1): 103–11. doi:10.1054/mehy.2001.1291. PMID 11421636.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.